New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis
| Autor: | Noelia Pérez-González, Nuria Bozal-de Febrer, Ana C. Calpena-Campmany, Anna Nardi-Ricart, María J. Rodríguez-Lagunas, José A. Morales-Molina, José L. Soriano-Ruiz, Francisco Fernández-Campos, Beatriz Clares-Naveros |
|---|---|
| Přispěvatelé: | [Pérez-González,N, Nardi-Ricart,A, Soriano-Ruiz,JL, Clares-Naveros,B] Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Campus of Cartuja, University of Granada, Granada, Spain. [Bozal-de Febrer,N] Department of Biology, Healthcare and the Environment, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. [Calpena-Campmany,AC] Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. [Calpena-Campmany,AC, Clares-Naveros,B] Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain. [Rodríguez-Lagunas,MJ] Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. [Rodríguez-Lagunas,MJ] Institute of Biomedicine, University of Barcelona, Barcelona, Spain. [Morales-Molina,JA] Department of Pharmacy, Torrecárdenas University Hospital, Almeria, Spain. [Fernández-Campos,F] Reig-Jofre Laboratories, Sant Joan Despi, Spain. [Clares-Naveros,B] Biosanitary Institute of Granada (ibs.GRANADA), Granada, Spain., This research was funded by the Spanish National Research Council (CSIC), project no. 202080E231, and the Agreement with the University of Barcelona and the University of Granada (Official State Gazette 311, on 27 November 2020). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Caspofungina
Polymers and Plastics Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Sensation [Medical Subject Headings] Science General. Including alchemy Mucoadhesive hydrogel Bioengineering Article Thermoreversible hydrogel mucoadhesive hydrogel Hidrogeles Diseases::Bacterial Infections and Mycoses::Mycoses::Candidiasis::Candidiasis Vulvovaginal [Medical Subject Headings] Biomaterials QD1-65 Candidiasis vulvovaginal Technology and Food and Beverages::Technology Industry and Agriculture::Manufactured Materials::Biomedical and Dental Materials::Polymers::Polyethylene Glycols::Poloxamer [Medical Subject Headings] Caspofungin caspofungin Chemicals and Drugs::Complex Mixtures::Colloids::Gels::Hydrogels [Medical Subject Headings] Malalties de l'aparell genital femení QD1-999 Antifungal therapy Antifungal agents Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases Female::Vaginal Diseases::Vaginal Discharge [Medical Subject Headings] QD146-197 thermoreversible hydrogel Medicaments antifúngics Vulvovaginal candidiasis Organic Chemistry Candidiasis Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Pruritus [Medical Subject Headings] Vaginal mucosal delivery Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antifungal Agents [Medical Subject Headings] Prurito antifungal therapy Chemistry Check Tags::Female [Medical Subject Headings] vulvovaginal candidiasis Candidiasi vaginal mucosal delivery Antifúngicos Female reproductive system diseases Inorganic chemistry Persons::Persons::Women [Medical Subject Headings] |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname Gels, Vol 7, Iss 259, p 259 (2021) Gels; Volume 7; Issue 4; Pages: 259 Gels Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | This research was funded by the Spanish National Research Council (CSIC), project no. 202080E231, and the Agreement with the University of Barcelona and the University of Granada (Official State Gazette 311, on 27 November 2020). Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC. Spanish National Research Council (CSIC), project no. 202080E231 Agreement with the University of Barcelona and the University of Granada |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|