Increased platelet activation and decreased fibrinolysis in the pathogenesis of aseptic necrosis of the femoral head

Autor:	K. Szepesi, M. Udvardy, Péter Batár, Levente Gáspár, Jolan Harsfalvi, E. Posan
Rok vydání:	1998
Předmět:	medicine.medical_specialty Aseptic necrosis business.industry Hematology General Medicine Disease Gastroenterology Pathogenesis Fibrinogen levels Femoral head medicine.anatomical_structure Internal medicine Immunology medicine Decreased fibrinolysis Platelet Platelet activation business
Zdroj:	Platelets. 9:233-235
ISSN:	1369-1635 0953-7104
DOI:	10.1080/09537109876753
Popis:	Thrombotic events, increased tendency toward intravascular thrombosis and decreased fibrinolysis seem to be possible pathologic causes for aseptic necrosis of the femoral head (ANFH) in adults. This project was to study whether either increased platelet activation or decreased fibrinolytic activity and/or any other thrombogenic factor may be implicated in the evolvement of ANFH. The speed of the in vitro lysis was significantly lower in patients (both in primary and in secondary cases) compared with healthy controls. The platelet activation (measuring with beta TG) proved to be significantly higher in the primary group as well as in the secondary group compared with healthy controls. Lp(a) levels were elevated in primary and secondary cases. This alteration was more characteristic in the primary cases. Fibrinogen levels were also elevated in the primary group, but the difference was not significant. The data shown here may further support that hypofibrinolysis and increased thrombogenesis are major causes of ANFH. Early diagnosis of ANFH increases the chances of modifying the course of this disabling disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdf638d74e11111b7b3904ce9edd7f0 https://doi.org/10.1080/09537109876753 Zobrazit plný text záznamu