Partial Small Bowel Resection with Sleeve Gastrectomy Increases Adiponectin Levels and Improves Glucose Homeostasis in Obese Rodents with Type 2 Diabetes
| Autor: | Jean Christophe Lifante, Manu M Sebastian, Rivka L. Shoulson, Luca Milone, William B. Inabnet, Judith Korner, Gift Kopsombut |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male Sleeve gastrectomy medicine.medical_specialty medicine.medical_treatment Type 2 diabetes Gastroenterology Impaired glucose tolerance Random Allocation Gastrectomy Glucagon-Like Peptide 1 Internal medicine Intestine Small Weight Loss medicine Animals Homeostasis Insulin Glucose homeostasis Obesity Glucose tolerance test medicine.diagnostic_test Adiponectin business.industry Glucose Tolerance Test medicine.disease Rats Rats Zucker Treatment Outcome Endocrinology Diabetes Mellitus Type 2 Surgery business Biomarkers |
| Zdroj: | World Journal of Surgery. 36:1432-1438 |
| ISSN: | 1432-2323 0364-2313 |
| Popis: | The aim of this study was to examine the effect of small bowel resection with and without sleeve gastrectomy on glucose homeostasis in an obese rodent model of type 2 diabetes.Zucker diabetic fatty rats were randomized into three surgical groups: Sham, small bowel resection, and small bowel resection with sleeve gastrectomy (BRSG). Weight and fasting glucose levels were measured at randomization and monitored after surgery. Oral glucose tolerance testing was performed at baseline and 45 days after surgery to assess glucose homeostasis and peptide changes.At baseline, all animals exhibited impaired glucose tolerance and showed no difference in weight or fasting (area under the curve) AUC(glucose). At sacrifice, Sham animals weighed more than BRSG animals (p = 0.047). At day 45, the Sham group experienced a significant increase in AUC(glucose) compared to baseline (p = 0.02), whereas there was no difference in AUC(glucose) in either surgical group at any time point: BR (p = 0.58) and BRSG (p = 0.56). Single-factor ANOVA showed a significant difference in AUC(glucose) of p = 0.004 between groups postoperatively: Sham (50,745 ± 11,170) versus BR (23,865 ± 432.6) (p = 0.01); Sham versus BRSG (28,710 ± 3188.8) (p = 0.02). There was no difference in plasma insulin, GLP-1, or adiponectin levels before surgery, although 45 days following surgery adiponectin levels where higher in the BRSG group (p = 0.004).Partial small bowel resection improved glucose tolerance independent of weight. The combination of small bowel resection and sleeve gastrectomy leads to an increase in adiponectin levels, which may contribute to improved glucose homeostasis. |
| Databáze: | OpenAIRE |
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