Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis
| Autor: | R J van de Stadt, I E van der Horst-Bruinsma, M M J Nielen, A R van der Horst, Dörte Hamann, L. A. Aarden, D. van Schaardenburg, B A C Dijkmans |
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| Přispěvatelé: | Clinical Immunology and Rheumatology, AII - Amsterdam institute for Infection and Immunity, General Internal Medicine, Landsteiner Laboratory, VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Pathology Immunology Arthritis Fibrinogen digestive system Gastroenterology Peptides Cyclic Severity of Illness Index General Biochemistry Genetics and Molecular Biology Fibrin Arthritis Rheumatoid Rheumatology immune system diseases Rheumatoid Factor Internal medicine medicine Immunology and Allergy Rheumatoid factor Humans skin and connective tissue diseases Aged Autoantibodies biology business.industry Autoantibody Odds ratio Middle Aged medicine.disease Prognosis Connective tissue disease digestive system diseases Extended Report Immunoglobulin M Rheumatoid arthritis biology.protein Citrulline Female business Epidemiologic Methods Biomarkers medicine.drug |
| Zdroj: | Annals of the rheumatic diseases, 64(8), 1199-1204. BMJ Publishing Group Annals of the Rheumatic Diseases, 64(8), 1199-1204. BMJ Publishing Group Nielen, MM, van der Horst, A R, van Schaardenburg, D, van der Horst-Bruinsma, I E, van de Stadt, RJ, Aarden, L A, Dijkmans, B A C & Hamann, D 2005, ' Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis ', Annals of the Rheumatic Diseases, vol. 64, no. 8, pp. 1199-1204 . https://doi.org/10.1136/ard.2004.029389 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2004.029389 |
| Popis: | Background: The anti-cyclic citrullinated peptide (CCP) test has a high sensitivity and specificity for rheumatoid arthritis, although CCP is not the physiological target of the autoantibodies. Citrullinated fibrin is abundant in inflamed synovium Objective: To assess the diagnostic and prognostic value of antibodies against citrullinated fibrinogen (ACF), a soluble precursor of fibrin, in comparison with IgM-rheumatoid factor (IgM-RF) and the second generation anti-CCP test. Methods: In 379 patients with early arthritis (258 rheumatoid and 121 undifferentiated), the sensitivity, specificity, and positive predictive value of ACF, anti-CCP, and IgM-RF for diagnosing rheumatoid arthritis were calculated. Multivariate logistic regression analysis was used to assess the diagnostic and prognostic value (radiographic progression after two years) of the tests. Results: The sensitivities of the ACF, anti-CCP, and IgM-RF tests were 55.8%, 57.8%, and 44.6%, with specificities of 92.6%, 94.2%, and 96.7%, respectively. Approximately 30% of the IgM-RF negative patients were positive for ACF or anti-CCP or both. The ACF and anti-CCP test had a high agreement in early arthritis (κ = 0.84). Of all baseline characteristics, the ACF test and the anti-CCP test were the best predictors for diagnosing rheumatoid arthritis at one year (odds ratio (OR) = 10.3 and 10.6, respectively) and for radiographic progression after two years (OR = 12.1 and 14.8). Conclusions: ACF is as sensitive as anti-CCP and more sensitive than IgM-RF in diagnosing rheumatoid arthritis in early arthritis. The ACF test is also a good predictor of radiographic progression, with a performance similar to the anti-CCP test. The ACF test and the anti-CCP test are especially valuable in IgM-RF negative arthritis. |
| Databáze: | OpenAIRE |
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