The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention
| Autor: | Dennis R. Taaffe, Harri Suominen, Jukka Puolakka, Jarmo Toivanen, Sarianna Sipilä, Sulin Cheng |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Physiology media_common.quotation_subject Adipose tissue Physical exercise Vertical jump Double-Blind Method Physiology (medical) Internal medicine medicine Hormone replacement therapy (male-to-female) Body Size Humans Muscle Skeletal Exercise Menstrual cycle media_common Analysis of Variance business.industry Body Weight Estrogen Replacement Therapy Skeletal muscle General Medicine Middle Aged medicine.disease Norethisterone acetate Postmenopause Menopause Endocrinology medicine.anatomical_structure Adipose Tissue Female Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1475-097X 1475-0961 |
| DOI: | 10.1111/j.1475-097x.2005.00628.x |
| Popis: | Hormone replacement therapy (HRT) has been reported to exert a positive effect on preserving muscle strength following the menopause, however, the mechanism of action remains unclear. We examined whether the mechanism involved preservation of muscle composition as determined by skeletal muscle attenuation. Eighty women aged 50-57 years were randomly assigned to either: HRT, exercise (Ex), HRT + exercise (ExHRT), and control (Co) for 1 year. The study was double-blinded with subjects receiving oestradiol and norethisterone acetate (Kliogest) or placebo. Exercise included progressive high-impact training for the lower limbs. Skeletal muscle attenuation in Hounsfield units (HU) was determined by computed tomography of the mid-thigh. Areas examined were the quadriceps compartment (includes intermuscular adipose tissue), quadriceps muscles, the posterior compartment and posterior muscles. Muscle performance was determined by knee extensor strength, vertical jump height, and running speed over 20 m. Fifty-one women completed the intervention. Vertical jump height and running speed improved in the HRT and ExHRT groups compared with Co (interaction, P < 0.01). For both the quadriceps compartment and quadriceps muscles, HU significantly increased (interaction, P |
| Databáze: | OpenAIRE |
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