Oxidized LDL and the metabolic syndrome
| Autor: | Dieuwke De Keyzer, Paul Holvoet, David R. Jacobs |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
business.industry Inflammation medicine.disease medicine.disease_cause Biochemistry Obesity Article Endocrinology Insulin resistance Weight loss Internal medicine medicine lipids (amino acids peptides and proteins) medicine.symptom Metabolic syndrome Risk factor business Dyslipidemia Oxidative stress |
| Zdroj: | Future Lipidology. 3:637-649 |
| ISSN: | 1746-0875 |
| DOI: | 10.2217/17460875.3.6.637 |
| Popis: | The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk. Oxidized LDL, a marker of lipoprotein-associated oxidative stress, is an emerging cardiovascular risk factor. In this review, we demonstrate that the metabolic syndrome exacerbates oxidized LDL in a feedback loop. We introduce molecular mechanisms underlying this loop. Finally, we demonstrate that weight loss and statin treatment lower metabolic syndrome factors associated with a reduction of oxidized LDL. The current data warrant further investigation into the role of lifestyle and therapeutic interventions that inhibit tissue-associated oxidation of LDL in the prevention of the metabolic syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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