Expression of stem cell markers in stroma of odontogenic cysts and tumors
| Autor: | Marilena Vered, Moran Chacham, Amos Buchner, Galit Almoznino, Ayelet Zlotogorski-Hurvitz |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Stromal cell Unicystic Ameloblastoma Dentigerous Cyst CD34 Odontogenic Tumors Biology Stem cell marker Odontogenic myxoma Pathology and Forensic Medicine Ameloblastoma 03 medical and health sciences 0302 clinical medicine medicine Humans Keratocyst Stem Cells 030206 dentistry medicine.disease Dentigerous cyst Otorhinolaryngology 030220 oncology & carcinogenesis Odontogenic Cysts Periodontics Oral Surgery medicine.symptom |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES. 49(10) |
| ISSN: | 1600-0714 |
| Popis: | BACKGROUND The stroma of odontogenic cysts/tumors may confer them differential biological behavior. We aimed to investigate the immunoexpression of stem cell markers (Nanog, SOX2, Oct4, and CD34) in the stroma of odontogenic cysts and tumors. CD34 was investigated exclusively as a marker for stromal fibroblast/fibrocyte cells (CD34 + SFCs). CD34 + SFCs were also investigated ultrastructurally. METHODS Ten cases each of primary odontogenic keratocyst (OKC), recurrent OKC, dentigerous cyst, ameloblastoma, unicystic ameloblastoma, odontogenic myxoma, and 7 syndromic OKC were included. Results were represented as the mean score (%) of positive cells/field for each marker for each study group. For CD34 + SFCs, results are presented as the mean number of cells/field for each type of lesion. Kruskal-Wallis and Spearman's correlation statistical tests were used; significance was set at P |
| Databáze: | OpenAIRE |
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