Association between TLR2 polymorphisms (- 196-174 Ins/Del, R677W, R753Q, and P631H) and schizophrenia in a Tunisian population
| Autor: | Besma Bel Hadj Jrad, Hana Saoud, Oumaima Inoubli, Lotfi Gaha, Ferid Zaafrane, Youssef Aflouk |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Tunisia Genotype Immunology medicine.disease_cause Polymorphism (computer science) Internal medicine medicine Genetic predisposition Humans Genetic Predisposition to Disease Allele Alleles Aged Polymorphism Genetic business.industry Haplotype Immune dysregulation Middle Aged medicine.disease Toll-Like Receptor 2 Genotype frequency Schizophrenia Female business |
| Zdroj: | Immunologic research. 69(6) |
| ISSN: | 1559-0755 |
| Popis: | Since immune dysregulation has been well studied in schizophrenia pathophysiology, recent studies showed a potent role of TLR2 in neuroinflammation process underlying schizophrenia pathogenesis. However, the genetic predisposition is still unclear. Thus, we hypothesized that TLR2 polymorphisms − 196–174 Ins/Del (rs111200466), R753Q (rs5743708), R677W (rs121917864), and P631H (rs5743704) could be involved in schizophrenia predisposition. A case–control study was performed on a Tunisian population composed of 250 healthy controls and 250 patients genotyped by PCR–RFLP. Genotype and allele distribution were evaluated with sex, schizophrenia subtypes, and other clinical features. We also assessed a haplotype analysis for TLR2 polymorphisms with schizophrenia. Our results showed higher ins/del genotype frequency in healthy women compared to patients (p = 0.006; OR = 0.2). In the other hand, logistic regression showed higher ins/del genotype frequency in controls compared to paranoid patients (p = 0.05; OR = 0.48, adjusted). Frequencies of CT and T allele of R677W were significantly higher in patients compared to controls (p |
| Databáze: | OpenAIRE |
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