Risk Factors of Invasive Pulmonary Fungal Infections in Patients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure
| Autor: | Liang Chen, Yuqing Feng, Baining Zhu, Caixia Yang, Xinchun He, Shigang Tang |
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| Rok vydání: | 2021 |
| Předmět: |
Hepatitis B virus
0303 health sciences medicine.medical_specialty Materials science Pulmonary Fungal Infections Article Subject medicine.disease_cause Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine T1-995 030211 gastroenterology & hepatology General Materials Science Acute on chronic liver failure In patient Technology (General) 030304 developmental biology |
| Zdroj: | Journal of Nanomaterials, Vol 2021 (2021) |
| ISSN: | 1687-4129 1687-4110 |
| DOI: | 10.1155/2021/9260259 |
| Popis: | To analyze the risk factors of invasive pulmonary fungal infections in patients with HBV-ACL, the clinical data and risk factors of 60 patients with HBV-ACLF complicated IPFI were analyzed retrospectively including clinical parameters, broad-spectrum antibiotics usage, neutropenia, invasive medical manipulations, serum total bilirubin, international normalized ratio (INR), and MELD scores were compared with non-IPFI. Risk factors were analyzed using mathematical tools. Candida species and Aspergillus were detected as the most prominent fungal strains (61.11% and 33.33%, respectively). The risk factors included prolong broad-spectrum antibiotic usage OR = 4.362 , P = 0.008 , neutropenia OR = 3.288 , P = 0.007 , invasive procedures OR = 3.263 , P = 0.010 , serum total bilirubin OR = 1.006 , P = 0.011 , INR OR = 2.101 , P = 0.007 , and MELD scores OR = 1.074 , P = 0.008 . Candida is the main IPFI strains in patients with HBV-ACLF. Broad-spectrum antibiotics usage, neutropenia, invasive manipulations, and the severity of ACLF might be risk factors for IPFI in patients with HBV-ACLF. |
| Databáze: | OpenAIRE |
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