Con: heparin-bonded cardiopulmonary bypass circuits do not represent a desirable and cost-effective advance in cardiopulmonary bypass technology
| Autor: | Rex L. Woolf, Monty G. Mythen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Cost-Benefit Analysis law.invention Blood loss law Internal medicine medicine Cardiopulmonary bypass Animals Humans Platelet Cardiopulmonary Bypass Heparin business.industry Antithrombin Extracorporeal circulation Anticoagulants Cardiac surgery Intact endothelium surgical procedures operative Anesthesiology and Pain Medicine Cardiology Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 12:710-712 |
| ISSN: | 1053-0770 |
| DOI: | 10.1016/s1053-0770(98)90249-x |
| Popis: | T HE INTACT ENDOTHELIUM, a complex biologic interface, is the perfect nonthrombogenic surface. The passage of blood through cardiopulmonary circuitry exposes the blood to a foreign surface and necessitates the use of heparin to reduce the incidence of thrombotic sequelae. Patients undergoing cardiac surgery requiring cardiopulmonary bypass (CPB) have an increased incidence of postoperative bleeding compared with nonbypass surgery. This is attributed to the hemostatic defects caused by CPB 1 and the administration of systemic heparin. 2 In addition, heparin has many side effects, such as allergic reactions, thrombocytopenia, and antithrombin III consumption. These factors may be responsible for some of the morbidity and mortality associated with CPB. In an attempt to ameliorate the impact of these features of CPB (ie, platelet and white cell activation), plastics technology was developed allowing the manufacture of heparin-bonded circuits (HBCs). 3 |
| Databáze: | OpenAIRE |
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