Lymphoepithelioma-like gastric carcinoma: an unusual consequence of Epstein-Barr virus infection in an HIV-infected woman
| Autor: | L Tsveniashvili, P Paniz-Mondolfi, J Balderacchi, Y Pang, S Cohen, Bruce Polsky, Emilia Mia Sordillo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Pathology medicine.medical_specialty Anti-HIV Agents Biopsy Hepatitis C virus Lymphoproliferative disorders Antineoplastic Agents HIV Infections Hepacivirus Dermatology Adenocarcinoma medicine.disease_cause Virus AIDS-Related Complex Immune Reconstitution Inflammatory Syndrome Stomach Neoplasms Carcinoma medicine Humans Pharmacology (medical) Epstein–Barr virus infection Aged Neoplasm Staging Lymphoepithelioma business.industry Public Health Environmental and Occupational Health medicine.disease Hepatitis C Virology Epstein–Barr virus Lymphoproliferative Disorders Treatment Outcome Infectious Diseases Nasopharyngeal carcinoma HIV-1 RNA Viral business |
| Zdroj: | International Journal of STD & AIDS. 24:59-62 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1258/ijsa.2012.012131 |
| Popis: | Lymphoepithelioma-like-gastric carcinoma (LEL-GC) is an Epstein-Barr virus (EBV)-associated neoplasm of the stomach reported to have a better prognosis than conventional gastric adenocarcinoma. Unlike other EBV-associated malignancies, particularly lymphoproliferative disorders and undifferentiated nasopharyngeal carcinoma, for which risk has been shown to increase in human immunodeficiency virus (HIV) infection, LEL-GC remains rare; only one HIV-infected patient with LEL-GC has been reported previously. We describe an aggressive case of EBV-associated LEL-GC in a woman co-infected with HIV 1 and hepatitis C virus. In situ hybridization of an endoscopic biopsy specimen for EBV-encoded small RNA confirmed the presence of this agent exclusively in the gastric cancer cells. Our patient had recently started antiretroviral therapy, suggesting that immune reconstitution may have been a factor in presentation of this tumour. |
| Databáze: | OpenAIRE |
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