Maternally transmitted resistance to lymphoma development in mice of reciprocal crosses of the RF/J and AKR/J strains
| Autor: | Frank Lilly, Maria L. Duran-Reynals, Allen Mayer, Francisco Duran Struuck |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Lymphoma viruses Mice Inbred Strains Spleen Thymus Gland General Biochemistry Genetics and Molecular Biology Virus Mice Mice Inbred AKR Pregnancy hemic and lymphatic diseases Murine leukemia virus medicine Animals Neoplasm Allele Gene Crosses Genetic biology Strain (chemistry) medicine.disease biology.organism_classification Virology Leukemia Virus Murine medicine.anatomical_structure Genes Female Rabbits |
| Zdroj: | Cell. 19:431-436 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/0092-8674(80)90517-6 |
| Popis: | Females but not males of the low-lymphoma RF/J strain transmit a non-Mendelian factor which suppresses the development of lymphoma in F1 crosses with mice of the high-lymphoma AKR/J strain. Suppression of lymphoma was also evident in the first backcross generation to the parental AKR strain, but only when (RF female x AKR male)F1 mice had been the female parent. This "maternal resistance factor" was transmitted independently of the dominant, lymphoma-suppressing Fv-1n allele transmitted by both males and females of the RF strain, but the suppressive capacities of the two factors appeared to be additive. In this cross, F1 progeny of RF females also showed marked suppression of ecotropic murine leukemia virus expression by comparison with mice of the reciprocal F1 cross, but this suppression of virus expression was not detected in the lymphoma-suppressed AKR backcross population. The observation of lymphoma suppression in the absence of ectropic virus suppression in mice of the (RF X AKR)F1 female x AKR male backross generation indicates a qualitative or quantitative difference in the determination of these two effects. |
| Databáze: | OpenAIRE |
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