Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin-like growth factor binding protein-1 and fetal fibronectin
| Autor: | Anna Vitulo, Marinella Dell’avanzo, Francesca Riboni, Delia M. Paternoster, Mario Plebani, Giuseppe Battagliarin |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Gestational Age Fetal Fibronectin Test Sensitivity and Specificity Insulin-like growth factor-binding protein Obstetric Labor Premature Predictive Value of Tests Pregnancy Risk Factors Internal medicine Prevalence medicine Humans Term delivery Prospective Studies False Negative Reactions Biochemical markers Fetal fibronectin biology business.industry Obstetrics and Gynecology General Medicine Human genetics Fibronectins Insulin-Like Growth Factor Binding Protein 1 Logistic Models Endocrinology Cervix Mucus biology.protein Phosphorylation Female business Biomarkers |
| Popis: | The aim of this study was to evaluate the efficacy of the phosphorylated insulin-like growth factor-binding protein (phIGFBP-1) and of the fetal fibronectin test (fFN) in predicting pre-term delivery in symptomatic women.We included 210 symptomatic women at 24-34 weeks' gestation, who underwent the phIGFBP-1 and fFN test. We analyzed the prevalence of pre-term delivery in these patients within 7 days upon admission, before the 34th and the 37th weeks' gestation.The 3.8% of women delivered within 7 days upon the admission, the 7.6% before 34 weeks and the 16.2% before 37 weeks' gestation. The phIGFBP-1 and fFN test had a high specificity and a high negative predictive value in predicting pre-term delivery within 7 days, before 34 and before 37 weeks' gestation. The logistic regression of phIGFBP-1 was statistically significant in predicting pre-term delivery with an odds ratio of 10.0834 weeks' gestation. The multivariate analysis showed that the phIGFBP test had a higher OR34 weeks' gestation (p0.001) and that the two variables were independent and useful in combination to predict pre-term delivery (37 weeks' gestation).The phIGFBP-1 test may be better that the fFN test in predicting pre-term delivery before 34 weeks' gestation. |
| Databáze: | OpenAIRE |
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