Pharmacological Effects of Peptides on Tracheal Smooth Muscle
| Autor: | J. Mizrahi, Réjean Couture, Domenico Regoli, S. Caranikas |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Physalaemin Muscle Relaxation Guinea Pigs Indomethacin Substance P Peptide In Vitro Techniques Inhibitory postsynaptic potential complex mixtures Guinea pig chemistry.chemical_compound Eledoisin Internal medicine Renin–angiotensin system medicine Animals Pharmacology chemistry.chemical_classification Chemistry Muscle Smooth General Medicine Trachea Endocrinology Carbachol Female Peptides Histamine Muscle Contraction Neurotensin |
| Zdroj: | Pharmacology. 25:39-50 |
| ISSN: | 1423-0313 0031-7012 |
| Popis: | Peptide and non-peptide agents were tested for their stimulatory or inhibitory effects on circular strips of guinea pig isolated tracheae. Substance P, eledoisin, physalaemin, neurotensin, angiotensin, histamine and carbachol were found to contract, while noradrenaline, dopamine, bradykinin, nucleotides (AMP, ADP, ATP) and prostaglandins (PGE1, PGE2, PGA2) induced concentration-dependent relaxations of tracheae contracted with substance P or carbachol. Indomethacin (2.8 X 10(-6) M) significantly potentiated the effect of substance P and blocked that of bradykinin. The contractions to substance P of tissues treated with indomethacin were not modified by atropine, methysergide, diphenhydramine, cimetidine, propranolol, phentolamine, [Leu8]-ATII, [Leu8]-des-Arg9-bradykinin, naloxone and baclofen. The order of potency of C-terminal fragments of substance P was: hexa(6-11) greater than hepta(5-11) greater than substance P greater than = octa(4-11). It is concluded that the guinea pig isolated trachea is a pharmacological preparation sensitive to numerous agents and useful for studying structure-activity relationship and the mechanism of cellular action of several peptides, particularly substance P. |
| Databáze: | OpenAIRE |
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