Family history of colorectal adenomatous polyps as a risk factor for colorectal cancer
| Autor: | K. Fukazawa, Hidenori Nakama, Bing Zhang, A. S. M. Abdul Fattah |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adenoma Colorectal cancer Rectum Gastroenterology Age Distribution Risk Factors Internal medicine Epidemiology medicine Carcinoma Humans Mass Screening Sex Distribution Risk factor Family history Aged business.industry Middle Aged medicine.disease Confidence interval Pedigree medicine.anatomical_structure Adenomatous Polyposis Coli Oncology Female Colorectal Neoplasms business |
| Zdroj: | European Journal of Cancer. 36:2111-2114 |
| ISSN: | 0959-8049 |
| Popis: | The aim of this study was to evaluate the risk of common colorectal cancer among first-degree relatives of patients with colorectal adenomatous polyps. In a population screening programme, 59406 subjects underwent an immunochemical faecal occult blood test. In a medical check-up-based cross-sectional study, 6139 subjects had a colonoscopic examination. They were divided into two groups, according to the results of a questionnaire on family history of colorectal adenomatous polyps, and the detection rates for colorectal cancer were compared in the groups positive or negative for a family history of colorectal adenomatous polyps. In the screening programme-based cross-sectional study, the detection rate for colorectal cancer was 0.57% (95% confidence interval (CI): 0.38-0.76) and 0.15% (95% CI: 0.12-0.18) in subjects with and without a family history of colorectal adenomatous polyps, respectively, showing a significant difference in the detection rate for colorectal cancer between the two groups (P0.05). In the medical check-up-based cross-sectional study, the detection rate for colorectal cancer was 2.31% (95% CI: 1.15-3.47) and 0.53% (95% CI: 0. 34-0.72) in subjects with and without a family history of colorectal adenomatous polyps, respectively, indicating a significant difference between the two groups (P0.05). These findings indicate that first-degree relatives of patients with colorectal adenomatous polyps have an elevated risk for common colorectal cancer, and that people with a family history of colorectal adenomatous polyps should be considered as a priority group for colorectal cancer screening. |
| Databáze: | OpenAIRE |
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