Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration
| Autor: | Klaus W. Lange |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Aging animal diseases Pyridinium Compounds Striatum Nervous System Diseases/chemically induced Receptors Dopamine chemistry.chemical_compound Spiperone/diagnostic use Behavior Animal/drug effects heterocyclic compounds Behavior Animal MPTP Dopaminergic Substantia Nigra Dopamine receptor 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Spiperone Systemic administration Receptors Dopamine/drug effects cardiovascular system Stereotyped Behavior/drug effects medicine.drug medicine.medical_specialty Substantia nigra Injections Internal medicine medicine Animals Pharmacology business.industry Neurotoxicity 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine/pharmacology MPTP Poisoning Rats Inbred Strains medicine.disease Aging/physiology nervous system diseases Rats Apomorphine Endocrinology chemistry nervous system 150 Psychologie ddc:150 Pyridinium Compounds/pharmacology Nervous System Diseases Stereotyped Behavior business Neuroscience |
| Zdroj: | European journal of pharmacology. 175(1) |
| ISSN: | 0014-2999 |
| Popis: | Unilateral intranigral injections of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridine) were given to young rats and unilateral intranigral injections of MPTP were given to old rats. MPTP in old rats and MPP+ in young rats induced ipsiversive circling for at least one week after injection and contraversive circling after the systemic administration of apomorphine; the number of D-2 receptors (Bmax) in the striatum of the injected hemisphere increased compared with that of control rats. MPTP in young rats induced only short-lasting ipsiversive circling and no contraversive circling after apomorphine; the number of striatal D-2 receptors did not increase. These results suggest that the neurotoxicity of MPTP is age-dependent in the rat, and that MPTP has neurotoxic effects on the nigrostriatal dopaminergic system in old rats and induces dopamine receptor supersensitivity in the denervated striatum. |
| Databáze: | OpenAIRE |
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