High norepinephrinergic orthostatic hypotension in early Parkinson's disease
| Autor: | Hiromasa Matsuno, Tadashi Umehara, Atsuo Nakahara, C. Toyoda, Hisayoshi Oka |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Supine position Parkinson's disease Vasopressins Blood Pressure 030204 cardiovascular system & hematology Sympathetic Denervation 03 medical and health sciences Orthostatic vital signs Hypotension Orthostatic 0302 clinical medicine Heart Rate Tilt-Table Test Internal medicine medicine Humans Cognitive decline Pure autonomic failure Radionuclide Imaging Aged Aged 80 and over business.industry Parkinson Disease Middle Aged medicine.disease Mental Status and Dementia Tests 3-Iodobenzylguanidine Neurology Cardiology Orthostatic stress Female Neurology (clinical) Geriatrics and Gerontology business Cognition Disorders Sesquiterpenes 030217 neurology & neurosurgery |
| Zdroj: | Parkinsonismrelated disorders. 55 |
| ISSN: | 1873-5126 |
| Popis: | Introduction Plasma norepinephrine concentration reflects lesions causing OH. We investigate whether patients with high norepinephrinergic orthostatic hypotension (OH) whose supine plasma norepinephrine concentration (NEsupine) is above the mean value in all patients with Parkinson's disease (PD) have central sympathetic denervation. Methods We analyzed data from 110 non-demented patients with early de novo PD who underwent cardiovascular examinations. We divided the patients into three groups according to the presence or absence of orthostatic hypotension and NEsupine: patients without OH, patients with OH+high NEsupine, and patients with OH+low NEsupine. Results The mean NEsupine in all patients was 251.6 pg/ml. Twelve patients (10.9%) had OH+high NEsupine (≥251.6 pg/ml), and 45 patients (40.9%) had OH+low NEsupine ( Conclusions Patient with PD and high norepinephrinergic OH are a subset of patients who have early cognitive decline and impaired vasopressin release. Vasopressin release after orthostatic stress was closely related to global cognition in PD. |
| Databáze: | OpenAIRE |
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