Poly(2-ethyl-2-oxazoline) Conjugates with Salicylic Acid via Degradable Modular Ester Linkages
| Autor: | Yann Bernhard, Ondrej Sedlacek, Joachim F. R. Van Guyse, Johan C. M. E. Bender, Richard Hoogenboom, Bruno G. De Geest, Zifu Zhong |
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| Přispěvatelé: | Universiteit Gent = Ghent University [Belgium] (UGENT), Laboratoire Lorrain de Chimie Moléculaire (L2CM), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Ecole Centrale de Lille-Université d'Artois (UA)-Centrale Lille Institut (CLIL) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Polymers and Plastics media_common.quotation_subject Bioengineering 02 engineering and technology Conjugated system 010402 general chemistry 01 natural sciences Biomaterials chemistry.chemical_compound Drug Delivery Systems Materials Chemistry Side chain Polyamines [CHIM]Chemical Sciences media_common chemistry.chemical_classification Esters Polymer 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences chemistry Drug delivery 0210 nano-technology Salicylic Acid Linker Salicylic acid Conjugate |
| Zdroj: | Biomacromolecules Biomacromolecules, American Chemical Society, 2020, 21 (8), pp.3207-3215. ⟨10.1021/acs.biomac.0c00659⟩ |
| ISSN: | 1525-7797 1526-4602 |
| DOI: | 10.1021/acs.biomac.0c00659⟩ |
| Popis: | International audience; Conjugation of drugs to polymers is a widely used approach to gain control over the release of therapeutics. In this contribution, salicylic acid, a multipurpose model drug, is conjugated to the biocompatible poly(2ethyl-2-oxazoline) (PEtOx). The drug is attached to the side chains of a polymer carrier through a hydrolytically cleavable ester linker, via a sequential postpolymerization modification. The chemical modulation of this ester, i.e., by primary or secondary alcohols, is demonstrated to greatly influence the ester hydrolysis rate. This crucial parameter allows us to tune the in vitro kinetics of the sustained drug release for periods exceeding a month in phosphate-buffered saline (PBS). The synthetic accessibility of the cleavable linker, together with the modularity of the drug release rate offered by this approach, highlights the utility of this class of polymers in the field of long-lasting drug delivery systems for persistent and chronic disease treatment. |
| Databáze: | OpenAIRE |
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