Tildipirosin: An effective antibiotic against Glaesserella parasuis from an in vitro analysis
Autor: | Miquel Collell Suriñach, Rafael Frandoloso, César B. Gutiérrez Martín, Luiz Carlos Kreutz, Priscila Rodrigues Peres, César Feronatod, Simone Ramos Prigol |
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Rok vydání: | 2020 |
Předmět: |
040301 veterinary sciences
medicine.drug_class Antibiotics Article Microbiology 0403 veterinary science Minimum inhibitory concentration Medicine Actinobacillus pleuropneumoniae Pig Minimal inhibitory concentration lcsh:Veterinary medicine General Veterinary biology Glaesserella parasuis business.industry Broth microdilution 0402 animal and dairy science Outbreak Tildipirosin 04 agricultural and veterinary sciences Antimicrobial biology.organism_classification 040201 dairy & animal science Glässer's disease lcsh:SF600-1100 Animal Science and Zoology business Bacteria |
Zdroj: | Veterinary and Animal Science, Vol 10, Iss, Pp 100136-(2020) Veterinary and Animal Science |
ISSN: | 2451-943X |
Popis: | Highlights • Glaesserella parasuis is highly susceptible to Tildipirosin. • Tildipirosin is recommended for treating Glässer's disease outbreaks. • MIC is the rational tool to survey the resistance of G. parasuis to tildipirosin. Tildipirosin is a latest generation macrolide that is used to battle infection diseases caused by Gram-negative bacteria. Recent studies have shown the effectiveness of this antimicrobial agent against Actinobacillus pleuropneumoniae; however, little information is available about Glaesserella parasuis, the etiological agent of Glässer's disease. In this study, the Tildipirosin activity to 100 Brazilian clinical isolates of G. parasuis was assessed using a broth microdilution assay. A total of 90% of G. parasuis isolates were sensitive at concentrations ≤ 4 µg/mL Tildipirosin, thus showing to be efficiently controlled by the therapeutic concentration recommended for pigs. On the other hand, a total of ten isolates have shown resistance to this antibiotic, with a minimal inhibitory concentration (MIC) ≥ 8 and ≤ 16 µg/ml. Notably, our findings highly support the use of Tildipirosin for treating Glässer's disease outbreaks, and it also advises the using of MIC approach to monitor the evolution of sensitivity or resistance exhibited by G. parasuis to this molecule, as well as to adjust therapeutic doses when necessary. |
Databáze: | OpenAIRE |
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