| Autor: |
Thomas Thibault, Bastien Durand-Bailloud, Agnès Soudry-Faure, Hélène Greigert, Clément Drouet, Hervé Devilliers, André Ramon, Yannick Bejot, Laurent Martin, Catherine Creuzot-Garcher, Nicolas Falvo, Sylvain Audia, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Rheumatology (Oxford, England). |
| ISSN: |
1462-0332 |
| Popis: |
Objectives To investigate the performance of cranial PET/CT for the diagnosis of GCA. Methods All patients with a suspected diagnosis of GCA were prospectively enrolled in this study and had a digital PET/CT with evaluation of cranial arteries if they had not started glucocorticoids >72 h previously. The diagnosis of GCA was retained after at least 6 months of follow-up if no other diagnosis was considered by the clinician and the patient went into remission after at least 6 consecutive months of treatment. Cranial PET/CT was considered positive if at least one arterial segment showed hypermetabolism similar to or greater than liver uptake. Results For cranial PET/CT, sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) were 73.3%, 97.2%, 91.7% and 89.7%, respectively. For extracranial PET/CT, diagnostic performance was lower (Se = 66.7%, Sp = 80.6%, PPV = 58.8%, NPV = 85.3%). The combination of cranial and extracranial PET/CT improved overall sensitivity (Se = 80%) and NPV (NPV = 90.3%) while decreasing overall specificity (Sp = 77.8%) and PPV (PPV = 60%). Conclusion Cranial PET/CT can be easily combined with extracranial PET/CT with a limited increase in examination time. Combined cranial and extracranial PET/CT showed very high diagnostic accuracy for the diagnosis of GCA. Trial registration ClinicalTrials.gov, https://clinicaltrials.gov, NCT05246540. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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