Decreased Serum Albumin Predicts Bleeding Events in Patients on Antiplatelet Therapy After Percutaneous Coronary Intervention
| Autor: | Dai Yamamoto, Takuya Sumi, Yohei Shibata, Susumu Suzuki, Toshiki Kawamiya, Yosuke Negishi, Hideki Ishii, Toyoaki Murohara, Kazuhiro Harada, Kenshi Hirayama, Toshijiro Aoki, Kazuhiro Kawashima, Ayako Kunimura, Yosuke Tatami |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Thienopyridine Pyridines medicine.medical_treatment Serum albumin Serum Albumin Human Postoperative Hemorrhage 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Hypoalbuminemia Adverse effect Aged Aged 80 and over Aspirin biology Proportional hazards model business.industry Percutaneous coronary intervention General Medicine Middle Aged medicine.disease Surgery Conventional PCI biology.protein Female Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Circulation Journal. 81:999-1005 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND Antiplatelet therapy (APT) after percutaneous coronary intervention (PCI) prevents ischemic events with increased risk of bleeding. Little is known about the relationship between hypoalbuminemia and bleeding risk in patients receiving APT after PCI. This study investigated the association between serum albumin level and bleeding events in this population.Methods and Results:We enrolled 438 consecutive patients who were prescribed dual APT (DAPT; aspirin and thienopyridine) beyond 1 month after successful PCI without adverse events. The patients were divided into 3 groups according to serum albumin tertile: tertile 1, ≤3.7 g/dL; tertile 2, 3.8-4.1 g/dL; and tertile 3, ≥4.2 g/dL. Adverse bleeding events were defined as Bleeding Academic Research Consortium criteria types 2, 3, and 5. During the median follow-up of 29.5 months, a total of 30 adverse bleeding events were observed. Median duration of DAPT was 14 months. The tertile 1 group had the highest risk of adverse bleeding events (event-free rate, 83.1%, 94.3% and 95.8%, respectively; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|