Tissue residue depletion of sulfaquinoxaline in turkey poults
| Autor: | Herbert F. Righter, George D. Lakata, H. Dwight Mercer |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Turkeys
Dose Physiology Kidney chemistry.chemical_compound Blood serum Quinoxalines Sulfaquinoxaline medicine Animals Pasteurella multocida Skin Sulfonamides biology Muscles Age Factors General Chemistry medicine.disease biology.organism_classification Blood proteins Coccidiosis medicine.anatomical_structure chemistry Liver Immunology Fowl cholera General Agricultural and Biological Sciences |
| Zdroj: | Journal of agricultural and food chemistry. 21(3) |
| ISSN: | 0021-8561 |
| Popis: | Sulfaquinoxaline was administered in the drink- incomplete between 0 and 3 days withdrawal in ing water to turkey poults, 11-12 weeks old, at a all tissues. The most rapid depletion occurred in prophylactic (0.0175%) or therapeutic (0.1%) muscle tissues; residues persisted longer in liver, dose for 7 days. Sulfonamide residues were deter- renal, and skin tissues. A withdrawal period in mined in breast muscle, liver, kidney, skin, and excess of 10 days is indicated for turkeys given blood serum at 0 (the morning following the last sulfaquinoxaline at these dosages under the conday of medication), 3, 5, 7, and 10 days post- ditionsof thisstudy. treatment. Residue depletion was rapid although Sulfaquinoxaline is useful for the treatment of coccidiosis in chickens and for the prevention and treatment of this disease in turkeys (Merck Veterinary Manual, 1967). Losses due to fowl typhoid in turkeys can often be reduced by giving sulfaquinoxaline in the drinking water. Administration of this drug at 0.1 or 0.05% in the feed was shown to offer possibilities in the prevention of enzootic Pasteurella infections in chickens, although no recognizable curative properties were indicated (Delaplane, 1945). Sulfaquinoxaline, sulfamethazine, and sulfamerazine were markedly effective in the prophylaxis of experimental fowl cholera in turkeys; sulfaquinoxaline was the most effective at low intake levels (0.01%) (Peterson, 1948). Administration of sulfaquinoxaline at 1.5 g/10 lb of feed or 1.5 oz/gal of water protected 12-week-old turkeys against heavy inoculation of Pasteurella multocida organisms when given at the time of or before infection (Richey and Morgan, 1957). Sulfaquinoxaline is preferred over the more common sulfonamides because of its greater accumulation and longer retention time in the blood (Schlenker and Simmons, 1950; Smith and Robinson, 1944). The high degree of binding to plasma proteins is believed to be related to the blood concentrations attained in chickens, as well as its ready penetration into the egg (Bankowski and Johnson, 1949). Sulfonamide residues in tissues and eggs of chickens administered sulfaquinoxaline at therapeutic and prophylactic doses have been determined (Righter et al., 1970). Residue depletion was most rapid in muscle and fat; residues persisted tor the longest time in renal tissues. Concentrations in egg yolks were high (greater than 0.1 ppm) at the tenth day after withdrawal. Tissue residue levels of sulfonamides in turkeys are either obscure or lacking. This study was undertaken in order to determine the amount and duration of tissue residues of sulfaquinoxaline in turkey poults. |
| Databáze: | OpenAIRE |
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