Selenium in chronic liver disease
| Autor: | P.J. Thuluvath, D.R. Triger |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Microgram Nutritional Status chemistry.chemical_element Chronic liver disease Excretion Selenium Liver disease Primary biliary cirrhosis Liver Function Tests Reference Values Internal medicine medicine Humans Aged Probability Hepatology medicine.diagnostic_test business.industry Liver Diseases Albumin Middle Aged medicine.disease Zinc Endocrinology Liver chemistry Chronic Disease Female Liver function tests business |
| Zdroj: | Journal of Hepatology. 14:176-182 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/0168-8278(92)90155-i |
| Popis: | In order to assess the role of selenium (Se) in chronic liver disease, we have measured serum, urinary and hepatic selenium in a range of liver diseases and correlated them with nutritional status and conventional liver biochemistry. Serum Se levels (microgram/l +/- S.D.) were significantly lower in both alcoholic (63.6 +/- 18.2, p less than 0.0001) and non-alcoholic liver disease (NALD) (60.6 +/- 13.6, p less than 0.0001) compared to healthy controls (87.8 +/- 21.2) and non-malignant 'disease controls' (80.3 +/- 19.1). Hepatic Se levels (microgram/g of dry weight) were also reduced in both ALD (0.568 +/- 0.647, p less than 0.005) and NALD (0.863 +/- 0.308, p less than 0.005) compared to controls (1.227 +/- 0.296), 24-h urinary Se excretion (microgram) in ALD (24.6 +/- 10.7) and NALD (29.0 +/- 14.3) was similar to controls (30.3 +/- 8.7). Serum Se showed a highly significant positive correlation with albumin (p less than 0.001) in both ALD and NALD. Serum levels were also significantly correlated with anthropometric measurements. Dietary assessment of patients with primary biliary cirrhosis and low serum Se levels did not show a reduced dietary intake. Our data show that Se levels are low in liver disease irrespective of aetiology and suggest that these low levels are more likely to be related to overall nutritional status than to dietary intake. |
| Databáze: | OpenAIRE |
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