Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy
| Autor: | Guilian Li, Zhengrong Yang, Hui Wang, Jin Zhao, Chenli Zheng, Jinquan Cheng, Xing Lv, Lin Chen, Xiaoxu Han, Lan Wei, Hao Li, Yanxiao Gao, Huachun Zou |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China medicine.medical_specialty Human immunodeficiency virus (HIV) HIV Infections CD4 count medicine.disease_cause Asymptomatic Gastroenterology Circulating recombinant form Men who have sex with men Young Adult Virology Internal medicine medicine Humans Homosexuality Male Phylogeny Disease progression biology business.industry Transmission (medicine) Research Sequence Analysis DNA RC581-607 Middle Aged Viral Load Antiretroviral therapy CD4 Lymphocyte Count Infectious Diseases HIV-1 biology.protein RNA Viral Immunologic diseases. Allergy medicine.symptom Antibody business Viral load |
| Zdroj: | Retrovirology Retrovirology, Vol 18, Iss 1, Pp 1-9 (2021) |
| DOI: | 10.21203/rs.3.rs-390294/v1 |
| Popis: | Background CRF55_01B is a newly identified HIV-1 circulating recombinant form originated from MSM in China. However, its impact on the disease progression and transmission risk has not been investigated. This study aimed to determine the impact of CRF55_01B infection on viral dynamics and immunological status so as to provide scientific evidence for further control and prevention effort on CRF55_01B. Linear mixed effect models were applied to evaluate CD4 cell count decline and viral load increase by subtype. Results Of the 3418 blood samples, 1446 (42.3%) were CRF07_BC, 1169 (34.2%) CRF01_AE, 467 (13.7%) CRF55_01B, 249 (7.3%) type B, and 87 (2.5%) other subtypes (CRF_08BC, CRF_01B, C). CRF55_01B had become the third predominant strain since 2012 in Shenzhen, China. CRF55_01B-infected MSM showed lower median of CD4 count than CRF07_BC-infected MSM (349.5 [IQR, 250.2–474.8] vs. 370.0 [IQR, 278.0–501.0], P Conclusions The relatively lower CD4 count and faster increase of plasma HIV RNA load of CRF55_01B-infected MSM without antiretroviral therapy suggest that CRF55_01B may lead to longer asymptomatic phase and higher risk of HIV transmission. Strengthened surveillance, tailored prevention strategies and interventions, and in-depth research focusing on CRF55_01B are urgently needed to forestall potential epidemic. |
| Databáze: | OpenAIRE |
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