Successful therapy with whole-lung lavage and autologous peripheral blood stem cell transplantation for pulmonary alveolar proteinosis complicating acute myelogenous leukemia
| Autor: | Akihiko Numata, Eijo Matsuishi, Kotaro Koyanagi, Yuichi Miyamoto, Hisashi Gondo, Koji Irie, Shuji Saito, Mine Harada |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Myeloid medicine.medical_treatment Pulmonary Alveolar Proteinosis Bronchoalveolar Lavage Transplantation Autologous Gastroenterology Myelogenous Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Peripheral Blood Stem Cell Transplantation Chemotherapy Hematology medicine.diagnostic_test business.industry Remission Induction medicine.disease Surgery Transplantation Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Bronchoalveolar lavage business Pulmonary alveolar proteinosis |
| Zdroj: | American Journal of Hematology. 81:107-109 |
| ISSN: | 1096-8652 0361-8609 |
| Popis: | A 43-year-old man with acute myelogenous leukemia (AML) was found to be complicated with pulmonary alveolar proteinosis (PAP), which was confirmed by biochemical and histological findings. After achievement of complete remission of AML, he underwent whole-lung lavages twice between intensive chemotherapies. Subsequently, he received high-dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT), which was performed safely without any infections. He has been in remission for 25 months after transplant with no recurrence of PAP. Autologous PBSCT in combination with whole-lung lavage may be a promising strategy in the treatment of PAP associated with hematological malignancies. |
| Databáze: | OpenAIRE |
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