Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

Autor: Ru Xu, Kun Zhang, Chen Su, Longlong Cui, Jingan Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Colorectal cancer
Cell
chemistry.chemical_element
Tumor cells
02 engineering and technology
macromolecular substances
010402 general chemistry
01 natural sciences
lcsh:Technology
Article
Ion
sodium alginate
medicine
General Materials Science
lcsh:Microscopy
Sodium alginate
lcsh:QC120-168.85
hydrogel sphere
lcsh:QH201-278.5
Chemistry
lcsh:T
technology
industry
and agriculture
Biomaterial
021001 nanoscience & nanotechnology
medicine.disease
copper ions
Copper
0104 chemical sciences
medicine.anatomical_structure
lcsh:TA1-2040
lcsh:Descriptive and experimental mechanics
colon cancer cells
lcsh:Electrical engineering. Electronics. Nuclear engineering
Swelling
medicine.symptom
0210 nano-technology
polyethyleneimine
lcsh:Engineering (General). Civil engineering (General)
lcsh:TK1-9971
Nuclear chemistry
Zdroj: Materials, Vol 12, Iss 9, p 1570 (2019)
Materials
Volume 12
Issue 9
ISSN: 1996-1944
Popis: Inhibition of residual malignant tumors in patients with colon cancer after operation is one of the difficulties in rehabilitation treatment. At present, using biocompatible materials to remove the copper ion which is the growth dependence of malignant tumors in the lesion site is considered to be the frontier means to solve this problem. In this work, we developed a sodium alginate (SA)/polyethyleneimine (PEI) hydrogel sphere via cross-linking method (SA/SP/SA
SP = SA/PEI) as an oral biomaterial for adsorbing and removing copper ions from colon cancer lesions. The evaluated results showed that the SA/PEI/SA (SPS) hydrogel sphere obtained the largest swelling rate at pH 8.3 which was the acid-base value of colon microenvironment and absorbed more copper ions compared with the SA control. The cell experiment presented that the SPS hydrogel sphere owned better compatibility on normal fibroblasts and promoted higher death of colon cancer cells compared with SA/PEI (SP) and SA control. Our data suggested that the SA/PEI hydrogel sphere had the potentiality as an oral biomaterial for inhibiting colon cancer cells.
Databáze: OpenAIRE
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