Estrogen Receptor Alpha Promotes Lupus in (NZB x NZW)F1 Mice in a B cell Intrinsic Manner
| Autor: | Dana E. Tabor, Karen A. Gould |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Immunology Antigens CD19 Lupus nephritis Kidney Article 03 medical and health sciences Mice 0302 clinical medicine Antigen immune system diseases medicine Immunology and Allergy Animals skin and connective tissue diseases B cell B-Lymphocytes Systemic lupus erythematosus biology Integrases Mice Inbred NZB Autoantibody Estrogen Receptor alpha medicine.disease Lupus Nephritis 030104 developmental biology medicine.anatomical_structure Antibodies Antinuclear Immunoglobulin G biology.protein Female Antibody Nephritis Estrogen receptor alpha 030215 immunology Signal Transduction |
| Popis: | Lupus is a systemic autoimmune disease characterized by the production of autoreactive antibodies against nuclear antigens. Women are disproportionately affected by lupus, and this sex bias is thought to be due, in large part, to the ability of estrogens to promote lupus pathogenesis. Previously, we have shown that global deletion of estrogen receptor alpha (ERα) significantly attenuated loss of tolerance, immune cell activation, autoantibody production, and the development of lupus nephritis. Here we show that targeted deletion of ERα specifically in B cells retards production of pathogenic autoantibodies and the development of nephritis in lupus-prone (NZB x NZW)F1 mice. Furthermore, we observed that ERα deletion in B cells was associated with decreased B cell activation in young, pre-autoimmune (NZB x NZW)F1 females. Altogether, these data suggest that ERα acts in a B cell-intrinsic manner to control B cell activation, autoantibody production, and lupus nephritis. |
| Databáze: | OpenAIRE |
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