Antioxidants activities and concentration of selenium, zinc and copper in preterm and IUGR human placentas
| Autor: | Renata Wietecha-Posłuszny, Halina Mrowiec, Stanisław Walas, Antoni Marcinek, Monika Zadrożna, Małgorzata Gawlik, Barbara Nowak, Paweł Zagrodzki |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Placenta chemistry.chemical_element Intrauterine growth restriction Dehydrogenase Biochemistry Antioxidants Inorganic Chemistry Superoxide dismutase Selenium chemistry.chemical_compound Pregnancy Internal medicine medicine Humans Cytochrome c oxidase reproductive and urinary physiology chemistry.chemical_classification Fetal Growth Retardation biology Glutathione peroxidase Glutathione medicine.disease Trace Elements Zinc Endocrinology medicine.anatomical_structure chemistry embryonic structures biology.protein Molecular Medicine Female Copper |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 23:144-148 |
| ISSN: | 0946-672X |
| DOI: | 10.1016/j.jtemb.2009.02.005 |
| Popis: | The aim of this study was to examine changes in activities of cytochrome c oxidase (CCO), glucose-6-phosphate dehydrogenase (G6PDH), Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) levels and copper (Cu), zinc (Zn) and selenium (Se) concentrations, and to assess the possible differences between preterm placentas, placentas from term pregnancies complicated by intrauterine growth restriction (IUGR) and full-term control placentas. The enzyme activities and the level of GSH decreased in IUGR and preterm placentas in comparison with the control group. CCO activity and GSH level in preterm placentas were markedly lower compared with the IUGR (P0.01; P0.05) and control (P0.01; P0.05) placentas, respectively. In IUGR placentas the level of Cu was reduced by 23% (P0.05) and Zn by 37%. In preterm placentas the level of Cu was reduced by 19% and Zn by 42%. Se level in IUGR and preterm placentas was higher (P0.05) by 28% and 32% than in control group, respectively. The strong relation was observed between birth weight and CCO activity, birth weight and Cu-Zn SOD activity, and a low level of Zn and Cu influenced the birth weight especially in IUGR cases. Moreover, the strong inverse correlation between Se level and birth weight, Se level and placental weight and Se level and CCO activity are new findings. |
| Databáze: | OpenAIRE |
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