Principles of Biomimetic Vascular Network Design Applied to a Tissue-Engineered Liver Scaffold
| Autor: | Joseph P. Vacanti, J. Randall Gilmore, Howard I. Pryor, David M. Hoganson, Owen Burns, Ira Spool |
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| Rok vydání: | 2010 |
| Předmět: |
Scaffold
Tissue engineered Tissue Engineering Tissue Scaffolds Iterative design Computer science Biomedical Engineering Biomimetic design Bioengineering Original Articles Biochemistry Technical design Biomaterials Liver Tissue engineering Vascular network Biomimetic Materials Blood Circulation Blood Vessels Solid organ ComputingMethodologies_COMPUTERGRAPHICS Biomedical engineering |
| Zdroj: | Tissue Engineering Part A. 16:1469-1477 |
| ISSN: | 1937-335X 1937-3341 |
| Popis: | Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow. |
| Databáze: | OpenAIRE |
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