Apoptosis Regulation Differs Between Ulcerative Colitis–Associated and Sporadic Colonic Tumors
| Autor: | Tsutomu Yoshida, Tetuo Mikami, Tadashi Motoori, Isao Okayasu, Fumiyuki Akino, Mioko Yajima |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adenoma
Pathology medicine.medical_specialty Survivin Crypt Apoptosis medicine.disease_cause Inhibitor of Apoptosis Proteins medicine Humans Cyclin D1 Cell growth business.industry Carcinoma Significant difference General Medicine medicine.disease Immunohistochemistry Ulcerative colitis digestive system diseases Neoplasm Proteins Colonic Neoplasms Colitis Ulcerative Carcinogenesis business Microtubule-Associated Proteins Cell Division |
| Zdroj: | American Journal of Clinical Pathology. 119:723-730 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/ylx4l4h36k54x92h |
| Popis: | To clarify kinetics in ulcerative colitis (UC)-associated lesions, cell proliferation, apoptosis, and expression of apoptosis-inhibitory proteins were studied. Ki-67 labeling and survivin and bcl-2 expression were examined immunohistochemically in 22 low-grade dysplasias (LGDs), 25 high-grade dysplasias (HGDs), and 13 adenocarcinomas associated with UC, and for comparison in 21 sporadic adenomas with LGD, 22 sporadic adenomas with HGD, and 21 invasive adenocarcinomas. Apoptosis was studied with nick-end labeling and immunohistochemical analysis of single-stranded DNA. In UC-associated LGDs, Ki-67--positive cells were more frequent in the lower than the upper half of the crypt, related to bcl-2 expression, while in sporadic adenomas such cells were more common in the upper half. No difference in apoptosis was found between UC-associated LGDs and sporadic adenomas with LGD or between UC-associated HGDs and sporadic adenomas with HGD. However, UC-associated carcinomas exhibited a lower apoptotic count than their sporadic invasive counterparts. This seemed related to higher survivin expression without a significant difference between the 2 types of invasive lesions regarding bcl-2 levels. Apoptosis is less frequent in UC-associated than in sporadic invasive colon carcinomas, this being linked to elevated survivin expression. The control of apoptosis may be different in the 2 types of tumorigenesis. |
| Databáze: | OpenAIRE |
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