Risk Factors for Campylobacteriosis of Chicken, Ruminant, and Environmental Origin: A Combined Case-Control and Source Attribution Analysis

Autor: Mughini Gras, L., Smid, J.H., Wagenaar, J.A., de Boer, A.G., Havelaar, A.H., Friesema, I.H.M., French, N.P., Busani, L., van Pelt, W., Advances in Veterinary Medicine, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Dep Infectieziekten Immunologie
Přispěvatelé: Advances in Veterinary Medicine, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Dep Infectieziekten Immunologie
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Bacterial Diseases
Veterinary medicine
Disease reservoir
Epidemiology
lcsh:Medicine
Population genetics
netherlands
medicine.disease_cause
Environmental - origin
disease burden
Campylobacteriosis
Risk Factors
Ruminant
Campylobacter Infections
Environmental Microbiology
Odds Ratio
infections
lcsh:Science
humans
fragment length polymorphism
Multidisciplinary
biology
Zoonotic Diseases
Campylobacter
Bacteriologie
Ruminants
Bacteriology
Host Pathogen Interaction & Diagnostics
Infectious Diseases
Veterinary Diseases
Medical Microbiology
Medicine
Research Article
Clinical Research Design
Microbiology
Infectious Disease Epidemiology
Confidence Intervals
medicine
Animals
Biology
Disease burden
Disease Reservoirs
new-zealand
Host Pathogen Interaction & Diagnostics
lcsh:R
association
Bacteriology
biology.organism_classification
medicine.disease
Host Pathogen Interactie & Diagnostiek
coli
jejuni clones
Case-Control Studies
Multivariate Analysis
Bacteriologie
Host Pathogen Interactie & Diagnostiek
Multilocus sequence typing
identification
Cattle
Veterinary Science
lcsh:Q
Chickens
Multilocus Sequence Typing
Zdroj: PLoS ONE 7 (2012) 8
PLoS ONE, 7(8)
PLoS One, 7(8). Public Library of Science
PLoS ONE, Vol 7, Iss 8, p e42599 (2012)
PLoS ONE
ISSN: 1932-6203
Popis: BACKGROUND: Campylobacteriosis contributes strongly to the disease burden of food-borne pathogens. Case-control studies are limited in attributing human infections to the different reservoirs because they can only trace back to the points of exposure, which may not point to the original reservoirs because of cross-contamination. Human Campylobacter infections can be attributed to specific reservoirs by estimating the extent of subtype sharing between strains from humans and reservoirs using multilocus sequence typing (MLST). METHODOLOGY/PRINCIPAL FINDINGS: We investigated risk factors for human campylobacteriosis caused by Campylobacter strains attributed to different reservoirs. Sequence types (STs) were determined for 696 C. jejuni and 41 C. coli strains from endemic human cases included in a case-control study. The asymmetric island model, a population genetics approach for modeling Campylobacter evolution and transmission, attributed these cases to four putative animal reservoirs (chicken, cattle, sheep, pig) and to the environment (water, sand, wild birds) considered as a proxy for other unidentified reservoirs. Most cases were attributed to chicken (66%) and cattle (21%), identified as the main reservoirs in The Netherlands. Consuming chicken was a risk factor for campylobacteriosis caused by chicken-associated STs, whereas consuming beef and pork were protective. Risk factors for campylobacteriosis caused by ruminant-associated STs were contact with animals, barbecuing in non-urban areas, consumption of tripe, and never/seldom chicken consumption. Consuming game and swimming in a domestic swimming pool during springtime were risk factors for campylobacteriosis caused by environment-associated STs. Infections with chicken- and ruminant-associated STs were only partially explained by food-borne transmission; direct contact and environmental pathways were also important. CONCLUSION/SIGNIFICANCE: This is the first case-control study in which risk factors for campylobacteriosis are investigated in relation to the attributed reservoirs based on MLST profiles. Combining epidemiological and source attribution data improved campylobacteriosis risk factor identification and characterization, generated hypotheses, and showed that genotype-based source attribution is epidemiologically sensible.
Databáze: OpenAIRE
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