Caudate nucleus volume mediates the link between glutamatergic neurotransmission and problematic smartphone use in youth
| Autor: | Hyun Hee Cho, Ji Won Chun, Jihye Choi, Jae Hyun Yoo, Mi Ran Choi, Jin-Young Kim, Dai Jin Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adolescent Caudate nucleus Glutamic Acid 030508 substance abuse Medicine (miscellaneous) Striatum Nucleus accumbens Impulsivity Synaptic Transmission 03 medical and health sciences Glutamatergic 0302 clinical medicine Internal medicine medicine Humans Putamen Glutamate receptor General Medicine 030227 psychiatry Behavior Addictive Psychiatry and Mental health Clinical Psychology Endocrinology Anxiety Smartphone Caudate Nucleus medicine.symptom 0305 other medical science Psychology |
| Zdroj: | Journal of Behavioral Addictions. 10:338-346 |
| ISSN: | 2063-5303 2062-5871 |
| DOI: | 10.1556/2006.2021.00024 |
| Popis: | Background and aimsProblematic smartphone use (PSU) is growing rapidly among teens. It has similar presentations as other behavioral addictions in terms of excessive use, impulse control problems, and negative consequences. However, the underlying neurobiological mechanisms remain undiscovered. We hypothesized that structural changes in the striatum might serve as an important link between alteration in glutamate signaling and development of PSU.MethodsAmong 88 participants, twenty (F:M, 12:8; age 16.2 ± 1.1) reported high scores in the smartphone addiction proneness scale (SAPS) with a cut-off score of 42; the other 68 (F:M, 19:49; age 15.3 ± 1.7) comprised the control group. Sociodemographic data and depression, anxiety, and impulsivity traits were measured. Striatal volumes (caudate, putamen, and nucleus accumbens) were estimated from T1 imaging data. Serum glutamate levels were estimated from peripheral blood samples. Group comparisons of each data were performed after controlling for age and gender. Mediation analyses were conducted to test the indirect effects of glutamate level alteration on PSU through striatal volumetric alteration.ResultsThe PSU group showed a decrease in both caudate volumes than the control group. Left caudate volume was positively correlated with serum glutamate level, and negatively with impulsivity traits and SAPS scores. The mediation model revealed a significant indirect effect of serum glutamate on SAS scores through the reduced left caudate volume.Discussion and conclusionsThis study suggests that altered glutamatergic neurotransmission may be associated with PSU among teens, possibly through reduced left caudate volume. Current findings might support neural mechanisms of smartphone addiction. |
| Databáze: | OpenAIRE |
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