Subgroup Analysis of US and Non-US Patients in a Global Study of High-Dose Donepezil (23 mg) in Moderate and Severe Alzheimer’s Disease
| Autor: | Joan Mackell, Yijun Sun, David S. Geldmacher, Jeffrey L. Cummings, Stephen Salloway, Jane Yardley, Jacobo Mintzer |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Agents Subgroup analysis Neuropsychological Tests Severity of Illness Index Gastroenterology Apolipoproteins E Double-Blind Method Piperidines Alzheimer Disease Memantine Internal medicine mental disorders medicine Humans Donepezil Adverse effect Psychiatry Nootropic Agents Aged Analysis of Variance Dose-Response Relationship Drug business.industry General Neuroscience Incidence (epidemiology) United States Clinical trial Psychiatry and Mental health Clinical Psychology Tolerability Concomitant Indans Drug Therapy Combination Female Geriatrics and Gerontology business medicine.drug |
| Zdroj: | American Journal of Alzheimer's Disease & Other Dementias®. 27:421-432 |
| ISSN: | 1938-2731 1533-3175 |
| Popis: | To better understand responses in the large number of US-based patients included in a global trial of donepezil 23 mg/d versus 10 mg/d for moderate-to-severe Alzheimer’s disease (AD), post hoc exploratory analyses were performed to assess the efficacy and safety in US and non-US (rest of the world [RoW]) patient subgroups. In both subgroups, donepezil 23 mg/d was associated with significantly greater cognitive benefits than donepezil 10 mg/d. Significant global function benefits of donepezil 23 mg/d over 10 mg/d were also observed in the US subgroup only. Compared with RoW patients, US patients had relatively more severe AD, had been treated with donepezil 10 mg/d for longer periods prior to the start of the study, and a higher proportion took concomitant memantine. In both subgroups, donepezil had acceptable tolerability; overall incidence of treatment-emergent adverse events was higher in patients receiving donepezil 23 mg/d compared with donepezil 10 mg/d. |
| Databáze: | OpenAIRE |
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