Assessing the NephroCheck® Test System in Predicting the Risk of Death or Dialysis in Burn Patients
| Autor: | Winfred N Stacey, Jeffrey T. Howard, Javance R Tercero, Ian J. Stewart, Jonathan A. Sosnov, Julie A Rizzo, Mithun R Suresh, Elizabeth H Babcock |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Poison control Sensitivity and Specificity law.invention 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Renal Dialysis law Internal medicine medicine Humans Prospective Studies Renal replacement therapy Prospective cohort study Dialysis business.industry Rehabilitation Acute kidney injury 030208 emergency & critical care medicine Acute Kidney Injury medicine.disease Intensive care unit Intensive Care Units Predictive value of tests Emergency Medicine Female Surgery Hemodialysis Burns business Biomarkers |
| Zdroj: | Journal of Burn Care & Research. 41:633-639 |
| ISSN: | 1559-0488 1559-047X |
| DOI: | 10.1093/jbcr/iraa008 |
| Popis: | Acute kidney injury (AKI) is associated with high mortality in burn patients. Urinary biomarkers can aid in the prediction of AKI and its consequences, such as death and the need for renal replacement therapy (RRT). The purpose of this study was to investigate a novel methodology for detecting urinary biomarkers, the NephroCheck® Test System, and assess its ability to predict death or the need for RRT in burn patients. Burn patients admitted to the United States Army Institute of Surgical Research (USAISR) burn intensive care unit were prospectively enrolled between March 2016 and April 2018. A urine sample was obtained from all study participants using the NephroCheck® system. Patient and injury characteristics were gathered, and descriptive statistics were calculated and multivariable logistic regression analyses were performed using these data. Of the 69 patients in this study, 15 patients (21.7%) attained the composite outcome of death or needing RRT within 30 days of urine collection. NephroCheck® scores were higher for patients with the composite outcome, with P = 0.06 for centrifuged scores and P = 0.04 for noncentrifuged scores. Centrifuged and noncentrifuged scores were in high agreement and correlation (R2 = 0.97, P < 0.0001). Noncentrifuged scores were significant in the unadjusted analysis, but they were not significant in the adjusted analysis. Although these scores had a lower sensitivity and negative predictive value compared with other parameters, they had the second highest specificity and positive predictive value. NephroCheck® scores were higher in burn patients with the composite outcome of death or needing RRT, and they demonstrated comparable sensitivity and specificity to creatinine and TBSA. |
| Databáze: | OpenAIRE |
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