Combined loss of expression of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma
| Autor: | Mutsuo Sekiguchi, Akiomi Ogawa, Kohji Miyazaki, Hiroyuki Yakushiji, Shiroh Matsukura, Yongxin Chen |
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| Rok vydání: | 2003 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty Methyltransferase Carcinoma Hepatocellular DNA Repair DNA repair DNA methyltransferase O(6)-Methylguanine-DNA Methyltransferase Medicine Humans neoplasms Adaptor Proteins Signal Transducing Aged Neoplasm Staging O6-methylguanine business.industry Liver Neoplasms Nuclear Proteins General Medicine HCCS Middle Aged medicine.disease Prognosis Immunohistochemistry digestive system diseases Neoplasm Proteins Gene Expression Regulation Neoplastic Oncology Tumor progression Hepatocellular carcinoma Cancer research Disease Progression Surgery Female business Carrier Proteins MutL Protein Homolog 1 |
| Zdroj: | Journal of surgical oncology. 82(3) |
| ISSN: | 0022-4790 |
| Popis: | Background and Objectives O6-methylguanine-DNA methyltransferase (MGMT) and human Mut L homologue 1 (hMLH1) are proteins that play an important role in DNA repair. No reports have yet described whether deficient MGMT and hMLH1 expression correlates with tumor progression and the prognosis of patients with hepatocellular carcinoma (HCC). Methods Using immunohistochemical analysis, we evaluated the expression status of MGMT and hMLH1 protein in 60 paraffin-embedded samples from consecutive patients with curatively resected HCC. Results The lack of expression of both MGMT and hMLH1 in HCCs (n = 7) correlated with advanced pTNM stage (P = 0.039), as compared with HCCs expressing both proteins (n = 25). The absence of both MGMT and hMLH1 was a significant indicator of malignant potential. The expression status of both MGMT and hMLH1 was a predictive factor for overall survival in patients with HCC (P |
| Databáze: | OpenAIRE |
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