Hypothyroidism in vasculitis
| Autor: | Christian Pagnoux, Antoine G. Sreih, David Cuthbertson, Curry L. Koening, Simon Carette, Kenneth J. Warrington, Nader Khalidi, Tanaz A. Kermani, Peter A. Merkel, Ulrich Specks, Larry W. Moreland, Philip Seo, Carol A. Langford, Carol A. McAlear, Paul A. Monach |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Takayasu's arteritis Microscopic Polyangiitis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Churg-Strauss Syndrome Gastroenterology Antibodies Antineutrophil Cytoplasmic Hypothyroidism Rheumatology Internal medicine Eosinophilic Humans Medicine Pharmacology (medical) Longitudinal Studies Prospective Studies Anti-neutrophil cytoplasmic antibody business.industry Polyarteritis nodosa Granulomatosis with Polyangiitis Clinical Science Middle Aged medicine.disease Giant cell arteritis Female business Microscopic polyangiitis Granulomatosis with polyangiitis Vasculitis |
| Zdroj: | Rheumatology (Oxford) |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/keab817 |
| Popis: | Objective To study the prevalence, risk and clinical associations of hypothyroidism among several forms of vasculitis. Methods Patients with GCA, Takayasu’s arteritis (TAK), PAN and the three forms of ANCA-associated vasculitis [AAV; granulomatosis with polyangiitis (GPA), microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (EGPA)] enrolled in a prospective, multicentre, longitudinal study were included. Results The study included data on 2085 patients [63% female, 90% White] with a mean age of 54.6 years (s.d. 17.2). Diagnoses were GCA (20%), TAK (11%), PAN (5%), GPA (42%), microscopic polyangiitis (8%) and EGPA (14%). Hypothyroidism was present in 217 patients (10%) (83% female), with a mean age 59.8 years (s.d. 14.5). Age- and sex-adjusted risk of hypothyroidism was GCA, odds ratio (OR) 0.61 (95% CI 0.41, 0.90); TAK, OR 0.57 (95% CI 0.31, 1.03); PAN, OR 0.59 (95% CI 0.25, 1.38); GPA, OR 1.51 (95% CI 1.12, 2.05); microscopic polyangiitis, OR 1.81 (95% CI 1.18, 2.80) and EGPA, OR 0.82 (95% CI 0.52, 1.30). Among patients with AAV, age- and sex-adjusted risk of hypothyroidism was higher with positive MPO-ANCA [OR 1.89 (95% CI 1.39, 2.76)]. The clinical manifestations of vasculitis were similar in patients with and without hypothyroidism, except transient ischaemic attacks, which were more frequently observed in patients with GCA and hypothyroidism (12% vs 2%; P = 0.001). Conclusions Differences in the risk of hypothyroidism among vasculitides may be due to genetic susceptibilities or immune responses. This study confirms an association of hypothyroidism with MPO-ANCA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|