Circadian regulation of depression: A role for serotonin
| Autor: | Rachel A. Daut, Laura K. Fonken |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Depressive Disorder Serotonin Depression Endocrine and Autonomic Systems Neurotransmitter systems Biology medicine.disease Article Circadian Rhythm 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Mood Circadian regulation medicine Animals Humans Major depressive disorder Disease Susceptibility Circadian rhythm Neuroscience Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Front Neuroendocrinol |
| ISSN: | 0091-3022 |
| DOI: | 10.1016/j.yfrne.2019.04.003 |
| Popis: | Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian system increases susceptibility to numerous pathological conditions including major depressive disorder. Stress is a common etiological factor in the development of depression and the circadian system is highly interconnected to stress-sensitive neurotransmitter systems such as the serotonin (5-hydroxytryptamine, 5-HT) system. Thus, here we propose that stress-induced perturbation of the 5-HT system disrupts circadian processes and increases susceptibility to depression. In this review, we first provide an overview of the basic components of the circadian system. Next, we discuss evidence that circadian dysfunction is associated with changes in mood in humans and rodent models. Finally, we provide evidence that 5-HT is a critical factor linking dysregulation of the circadian system and mood. Determining how these two systems interact may provide novel therapeutic targets for depression. |
| Databáze: | OpenAIRE |
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