Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection
| Autor: | Fátima Santos, Daniela Leite Fabrino, Rodrigo Nunes Rodrigues-da-Silva, Daiana de Souza Perce-da-Silva, Dalma Maria Banic, Virginia Araujo Pereira, Joseli Oliveira-Ferreira, Josué da Costa Lima-Junior, Fabio Luiz Storer |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Adult Blood Platelets Male lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Neutrophils Plasmodium vivax lcsh:QR1-502 malaria Inflammation Enzyme-Linked Immunosorbent Assay Nitric Oxide lcsh:Microbiology Nitric oxide C-reactive protein chemistry.chemical_compound nitric oxide parasitic diseases medicine Malaria Vivax Humans Platelet Malaria Falciparum biology Plasmodium falciparum Convalescence biology.organism_classification medicine.disease Cell counting C-Reactive Protein chemistry Immunology Acute Disease biology.protein Female band neutrophils medicine.symptom Inflammation Mediators Malaria |
| Zdroj: | Memórias do Instituto Oswaldo Cruz, Volume: 107, Issue: 8, Pages: 1035-1041, Published: DEC 2012 Memórias do Instituto Oswaldo Cruz., Vol 107, Iss 8, Pp 1035-1041 (2012) |
| Popis: | The haematological changes and release of soluble mediators, particularly C-reactive protein (CRP) and nitric oxide (NO), during uncomplicated malaria have not been well studied, especially in Brazilian areas in which the disease is endemic. Therefore, the present study examined these factors in acute (day 0) and convalescent phase (day 15) patients infected with Plasmodium falciparum and Plasmodium vivax malaria in the Brazilian Amazon. Haematologic parameters were measured using automated cell counting, CRP levels were measured with ELISA and NO plasma levels were measured by the Griess reaction. Our data indicate that individuals with uncomplicated P. vivax and P. falciparum infection presented similar inflammatory profiles with respect to white blood cells, with high band cell production and a considerable degree of thrombocytopaenia during the acute phase of infection. Higher CRP levels were detected in acute P. vivax infection than in acute P. falciparum infection, while higher NO was detected in patients with acute and convalescent P. falciparum infections. Although changes in these mediators cannot predict malaria infection, the haematological aspects associated with malaria infection, especially the roles of platelets and band cells, need to be investigated further. |
| Databáze: | OpenAIRE |
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