Factors associated with radiographic lesions in early axial spondyloarthritis. Results from the DESIR cohort
| Autor: | Bijan Ghaleh, Aurélie Lethuaut, M. Blachier, Cécile Poulain, Valérie Farrenq, Bruno Fautrel, Pascal Claudepierre, Philippe Le Corvoisier, Salah Ferkal, Florence Canoui-Poitrine, Sylvie Bastuji-Garin, Maxime Dougados |
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| Přispěvatelé: | Laboratoire d'Investigation Clinique (LIC), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle Recherche Clinique-Santé Publique [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor, Service de rhumatologie [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Rhumatologie, Université Paris Diderot - Paris 7 (UPD7), CIC - CHU Henri Mondor, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de rhumatologie [CHU Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri-Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) - Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10, Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Rok vydání: | 2013 |
| Předmět: |
MESH: Inflammation
Male [SDV]Life Sciences [q-bio] Radiography MESH : Sacroiliac Joint MESH : Prospective Studies Severity of Illness Index MESH: Magnetic Resonance Imaging Cohort Studies 0302 clinical medicine Epidemiology MESH : Anti-Inflammatory Agents Non-Steroidal MESH : Female Pharmacology (medical) Longitudinal Studies Prospective Studies MESH: Sacroiliac Joint MESH: Longitudinal Studies MESH: Cohort Studies MESH : Longitudinal Studies 0303 health sciences MESH: Middle Aged medicine.diagnostic_test Anti-Inflammatory Agents Non-Steroidal MESH : Spondylarthritis MESH : Adult Middle Aged MESH: Anti-Inflammatory Agents Non-Steroidal Magnetic Resonance Imaging 3. Good health [SDV] Life Sciences [q-bio] Cohort MESH : Severity of Illness Index Female Radiology MESH: Spine Adult medicine.medical_specialty Alcohol Drinking MESH : Male MESH: Spondylarthritis MESH : Cohort Studies 03 medical and health sciences Lumbar Rheumatology MESH : Magnetic Resonance Imaging MESH: Severity of Illness Index Spondylarthritis MESH : Spine medicine Humans MESH : Middle Aged Spondylarthropathies 030304 developmental biology Inflammation 030203 arthritis & rheumatology Ankylosing spondylitis MESH : Inflammation MESH: Humans business.industry MESH : Humans Sacroiliitis MESH: Adult Sacroiliac Joint Magnetic resonance imaging medicine.disease MESH: Prospective Studies MESH: Male Spine Surgery MESH : Alcohol Drinking business MESH: Female MESH: Alcohol Drinking |
| Zdroj: | Rheumatology Rheumatology, Oxford University Press (OUP), 2013, 52 (9), pp.1686-93. ⟨10.1093/rheumatology/ket207⟩ Rheumatology, Oxford University Press (OUP), 2013, 52 (9), pp.1686-93. 〈10.1093/rheumatology/ket207〉 |
| ISSN: | 1462-0332 1462-0324 1460-2172 |
| DOI: | 10.1093/rheumatology/ket207 |
| Popis: | International audience; OBJECTIVE: To assess whether factors such as inflammation by laboratory tests and MRI differ between early axial SpA with and without radiographic lesions. METHODS: Cross-sectional analysis of baseline data from Devenir des Spondylarthropathies Indifferenciées Récentes (DESIR) cohort patients having recent-onset inflammatory back pain and meeting Assessment of SpondyloArthritis international Society criteria. The baseline evaluation included radiographs and MRI of the SI joints (SIJs) and spine. Patients were classified as having radiographic lesions if they had at least one obvious sacroiliitis, grade 2 for at least one vertebral corner or grade 1 for at least two vertebral corners (at the cervical or lumbar level, according to the modified Stoke Ankylosing Spondylitis Spine Score). Associations between baseline characteristics and the presence of radiographic lesions were evaluated by estimating multi-adjusted odd ratios (aORs) and their 95% CIs using a logistic regression model. RESULTS: Of 475 patients, 180 (37.9%) had radiographic lesions. Factors positively associated with radiographic lesions were alcohol use (aOR 2.42; 95% CI 1.31, 4.44; P = 0.005), CRP level (aOR 1.44; 95% CI 1.13, 1.84; P = 0.003) and SIJ inflammation by MRI (aOR 2.25; 95% CI 1.40, 3.60; P = 0.001); negative associations occurred with good NSAID responsiveness (aOR 0.44; 95% CI 0.24, 0.81; P = 0.008); spinal MRI inflammation was associated with radiographic lesions only in smokers (aOR 1.99; 95% CI 1.01, 3.92; P = 0.048). CONCLUSION: Alcohol use, poor responsiveness to NSAIDs, CRP elevation, SIJ MRI inflammation and spinal MRI inflammation in smokers were independently associated with radiographic lesions in early axial SpA. |
| Databáze: | OpenAIRE |
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