TCR-Seq Identifies Distinct Repertoires of Distant-Metastatic and Nondistant-Metastatic Thyroid Tumors
| Autor: | Chao Zhang, Chuan-Ming Zheng, Minghua Ge, Changxi Wang, Yi Huang, Jiafeng Wang, Xin Zhu, Xia-Bin Lan, Qihong Zhang, Jiajie Xu, Wei Wei, Chunliu Zhang, Ke Ye, Xinyang Ge, Chao Chen, Xin Yi, Jun Cao, Zaixian Tai, Xuhang Zhu, Zhuo Tan |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Receptors Antigen T-Cell Biochemistry Papillary thyroid cancer Metastasis Lymphocytes Tumor-Infiltrating Endocrinology Malignant Thyroid Tumor Internal medicine medicine Humans Thyroid Neoplasms Thyroid Nodule Neoplasm Metastasis Thyroid tumors Thyroid cancer Aged Retrospective Studies Aged 80 and over business.industry Biochemistry (medical) T-cell receptor Thyroid Area under the curve High-Throughput Nucleotide Sequencing Middle Aged medicine.disease Gene Expression Regulation Neoplastic medicine.anatomical_structure Thyroid Cancer Papillary Case-Control Studies Genes T-Cell Receptor beta Female Neoplasm Recurrence Local business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 105:3036-3045 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context Malignant thyroid tumor with distant metastasis is associated with poor outcome. Early detection of distant metastasis is of great clinical importance. Objective Thyroid tumor infiltrated with T cells can serve as a biomarker for monitoring metastasis. Design A retrospective analysis was performed of patient clinical samples collected between 2012 to 2018, using T-cell receptor sequencing (TCR-seq) for clinical exploration. Setting This study took place at Zhejiang Cancer Hospital. Patients Sixty-eight patients with papillary thyroid cancer (PTC) (distinct metastatic status) and 21 patients with benign nodules were enrolled. All patients had not received any treatment before surgery. Main Outcome Measure The characteristics of TCRβ complementary-determining region 3 (CDR3) for each patient were determined by high-throughput sequencing. Results The TCRβ diversity of malignant tumors is significantly higher than benign nodules both in blood and tumor samples (Shannon index, blood, P Conclusion The availability and reliability of TCR-seq render it prospective to translate these intrinsic attributes into clinical practice for monitoring distant metastasis in PTC patients. |
| Databáze: | OpenAIRE |
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