Natural polymorphisms and resistance-associated mutations in the fusion protein of respiratory syncytial virus (RSV): effects on RSV susceptibility to palivizumab
| Autor: | Michael P. McCarthy, Josephine M. McAuliffe, Nita K. Patel, JoAnn Suzich, Wei Zhu, Qing Zhu, Leslie Wachter |
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| Rok vydání: | 2011 |
| Předmět: |
Palivizumab
Mutation Missense Drug resistance medicine.disease_cause Antibodies Monoclonal Humanized Antiviral Agents Virus Epitopes Antigen Drug Resistance Viral medicine Immunology and Allergy Humans Antigens Viral Polymorphism Genetic biology Infant Newborn Infant Virology Fusion protein Respiratory Syncytial Viruses Infectious Diseases Respiratory syncytial virus (RSV) Child Preschool Monoclonal biology.protein Antibody Viral Fusion Proteins medicine.drug |
| Zdroj: | The Journal of infectious diseases. 205(4) |
| ISSN: | 1537-6613 |
| Popis: | Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance. We assessed the incidence of sequence polymorphisms and palivizumab resistance in clinical RSV isolates collected from immunoprophylaxis-naive subjects. Polymorphisms were identified at low frequency, and only polymorphic mutations in antigenic site A ( |
| Databáze: | OpenAIRE |
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