Recent Developments on Phenstatins as Potent Antimitotic Agents
| Autor: | Grant A. L. Bare, Xing Chen, Syed Nasir Abbas Bukhari, Shi-Meng Wang, Gajjela Bharath Kumar, Hua-Li Qin, Jing Leng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Research literature
Mitosis Antineoplastic Agents Pharmacology Antimitotic Agents 010402 general chemistry 01 natural sciences Biochemistry Benzophenones Tubulin Colchicine binding Drug Discovery Structure–activity relationship Humans Cytotoxicity Cell Proliferation 010405 organic chemistry Chemistry Organic Chemistry Cell Cycle Phenstatin 0104 chemical sciences Review article Molecular Medicine Antimitotic Agent Clinical evaluation |
| Zdroj: | Current medicinal chemistry. 25(20) |
| ISSN: | 1875-533X |
| Popis: | Background: Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing various derivatives with profound antimitotic activity and excellent cytotoxicity. Objective: To do analysis of literature that phenstatins derivatives inhibit tubulin polymerization through their interaction at the colchicine binding site of microtubules and arrest the G2/M phase of the cell cycle. In addition, phenstatin derivatives are undergoing clinical evaluation as vascular targeting/disrupting agents and also exhibit direct antiangiogenic properties. Methods: An organised well designed and appropriately managed search of bibliographic databases for peer-reviewed research literature using a focused review question and inclusion/ exclusion criteria has been done for this article. Conclusion: In this review article, the synthesis and structure-activity relationships of phenstatin and a wide number of their reported analogues with modifications to ring A, ring B, and to the keto position are discussed in the perspective of medicinal chemistry with proper conclusion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|