Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

Autor: Francisco J. Calderón, Yannis P. Pitsiladis, Teresa Amigo, Guan Wang, Pedro J. Benito, Domingo González-Lamuño, Carmen Gómez-Candela, Rocío Cupeiro, Barbara Szendrei
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Arginine
Physiology
Endocrinology
Diabetes and Metabolism
Overweight
Body Mass Index
0302 clinical medicine
Weight loss
Young adult
Adiposity
2. Zero hunger
Nutrition and Dietetics
General Medicine
Middle Aged
Combined Modality Therapy
Exercise Therapy
Phenotype
Treatment Outcome
Body Composition
Female
medicine.symptom
Adult
medicine.medical_specialty
Adolescent
Genotype
Medicina
030209 endocrinology & metabolism
Polymorphism
Single Nucleotide
03 medical and health sciences
Young Adult
Physiology (medical)
Internal medicine
Weight Loss
medicine
Lipolysis
Humans
Obesity
Caloric Restriction
Deportes
business.industry
Resistance Training
medicine.disease
Glutamine
030104 developmental biology
Endocrinology
Spain
Receptors
Adrenergic
beta-3
Physical Endurance
Receptors
Adrenergic
beta-2
business
Body mass index
Zdroj: Applied Physiology, Nutrition and Metabolisim, ISSN 1715-5320, 2016, Vol. 41, No. 3
Applied Physiology Nutrition and Metabolism, ISSN 1715-5312, 2016, Vol. 41, No. 3
Archivo Digital UPM
Universidad Politécnica de Madrid
Popis: The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.
Databáze: OpenAIRE
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