Host type 2 immune response to xenogeneic serum components impairs biomaterial-directed osteo-regenerative therapies

Autor:	Karen E. Martin, Pranav P. Kalelkar, María M. Coronel, Hannah S. Theriault, Rebecca S. Schneider, Andrés J. García
Rok vydání:	2022
Předmět:	Biomaterials Mice Osteogenesis Mechanics of Materials Immunity Biophysics Ceramics and Composites Animals Biocompatible Materials Cell Differentiation Hydrogels Mesenchymal Stem Cells Bioengineering
Zdroj:	Biomaterials. 286:121601
ISSN:	0142-9612
DOI:	10.1016/j.biomaterials.2022.121601
Popis:	The transformative potential of cells as therapeutic agents is being realized in a wide range of applications, from regenerative medicine to cancer therapy to autoimmune disorders. The majority of these therapies require ex vivo expansion of the cellular product, often utilizing fetal bovine serum (FBS) in the culture media. However, the impact of residual FBS on immune responses to cell therapies and the resulting cell therapy outcomes remains unclear. Here, we show that hydrogel-delivered FBS elicits a robust type 2 immune response characterized by infiltration of eosinophils and CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baa68a57eb9b822a603b08bceaaa93d https://doi.org/10.1016/j.biomaterials.2022.121601 Zobrazit plný text záznamu Full Text from ScienceDirect