Evaluation of monkeypox disease progression by molecular imaging
| Autor: | Jason Paragas, Russell Byrum, Dar-Yeong Chen, Gerald B. Jennings, Peter B. Jahrling, Reed F. Johnson, Louis Huzella, Dan R. Ragland, R.C. Reba, Joseph E. Blaney, Daniel J. Mollura, Julie Dyall |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Axillary lymph nodes Inflammation Bronchi Disease Multimodal Imaging Monkeypox Necrosis Major Articles and Brief Reports Fluorodeoxyglucose F18 Immunology and Allergy Medicine Animals Monkeypox virus Lung Fluorodeoxyglucose medicine.diagnostic_test biology business.industry Pneumonia medicine.disease biology.organism_classification Disease Models Animal Macaca fascicularis Infectious Diseases medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Immunology Axilla Injections Intravenous Disease Progression Female Lymph Nodes medicine.symptom business Tomography X-Ray Computed medicine.drug |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 |
| Popis: | Infection of nonhuman primates (NHPs) with monkeypox virus (MPXV) is currently being developed as an animal model of variola infection in humans. We used positron emission tomography and computed tomography (PET/CT) to identify inflammatory patterns as predictors for the outcome of MPXV disease in NHPs. Two NHPs were sublethally inoculated by the intravenous (IV) or intrabronchial (IB) routes and imaged sequentially using fluorine-18 fluorodeoxyglucose ((18)FDG) uptake as a nonspecific marker of inflammation/immune activation. Inflammation was observed in the lungs of IB-infected NHPs, and bilobular involvement was associated with morbidity. Lymphadenopathy and immune activation in the axillary lymph nodes were evident in IV- and IB-infected NHPs. Interestingly, the surviving NHPs had significant (18)FDG uptake in the axillary lymph nodes at the time of MPXV challenge with no clinical signs of illness, suggesting an association between preexisting immune activation and survival. Molecular imaging identified patterns of inflammation/immune activation that may allow risk assessment of monkeypox disease. |
| Databáze: | OpenAIRE |
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