Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing
| Autor: | Wenhao Pan, Xiaoliang Qi, Yajing Xiang, Shengye You, Erya Cai, Teng Gao, Xianqin Tong, Rongdang Hu, Jianliang Shen, Hui Deng |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Chitosan Staphylococcus aureus Wound Healing Microbial Viability Hydrogels General Medicine Bandages Biochemistry Streptozocin Anti-Bacterial Agents Diabetes Mellitus Experimental Injections Rats Treatment Outcome Structural Biology Escherichia coli Animals Collagen Reactive Oxygen Species Tannins Molecular Biology |
| Zdroj: | International Journal of Biological Macromolecules. 195:190-197 |
| ISSN: | 0141-8130 |
| Popis: | The wound healing process of the diabetic wound is often hindered by excessive oxygen free radicals and infection. An ideal wound dressing should possess great reactive oxygen species (ROS) scavenging property and considerable antibacterial ability. In this study, we facilely constructed a novel hydrogel dressing with excellent ROS scavenging property and outstanding antibacterial performance by introducing tannic acid (TA) into quaternized chitosan (QCS) matrix. Attributing to the suitable physical crosslinking between TA and QCS, this QCS/TA hydrogel was endowed with injectable and self-healing properties, which could avoid the various external squeezing on the irregular shape by wound dressing. The results showed that it could promote coagulation, suppress inflammation and expedite collagen deposition in the skin defect model of diabetic rats. This study provides a facile and convenient method for constructing injectable hydrogel dressing, which has application potentials in the clinical management of diabetic wounds. |
| Databáze: | OpenAIRE |
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