Effects of anesthesia, surgery, and intravenous administration of fluids on plasma antidiuretic hormone concentrations in healthy dogs
| Autor: | Ray F. Nachreiner, Sheri L. Wood, Marlee A. Richter, Joe G. Hauptman |
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| Rok vydání: | 2000 |
| Předmět: |
Vasopressin
medicine.medical_specialty Vasopressins Blood Pressure Urine Body weight Body Temperature Inappropriate ADH Syndrome Dogs Tidal Volume Animals Medicine Anesthesia Dog Diseases Urine output General Veterinary business.industry Osmolar Concentration General Medicine Surgery Plasma osmolality Blood pressure Hematocrit Surgical Procedures Operative Injections Intravenous Fluid Therapy business Hormone Antidiuretic |
| Zdroj: | American Journal of Veterinary Research. 61:1273-1276 |
| ISSN: | 0002-9645 |
| Popis: | Objective—To evaluate effects of anesthesia, surgery, and intravenous administration of fluids on plasma concentrations of antidiuretic hormone (ADH), concentration of total solids (TS), PCV, arterial blood pressure (BP), plasma osmolality, and urine output in healthy dogs. Animals—22 healthy Beagles. Procedure—11 dogs did not receive fluids, and 11 received 20 ml of lactated Ringer's solution/kg of body weight/h. Plasma ADH adn TS concentrations, PCV, osmolality, and arterial BP were measured before anesthesia (T0) and after administration of preanesthetic agents (T1), induction of anesthesia (T2), and 1 and 2 hours of surgery (T3 and T4, respectively). Urine output was measured at T3 and T4. Results—ADH concentrations increased at T1, T3, and T4, compared with concentrations at T0. Concentration of TS and PCV decreased at all times after administration of preanesthetic drugs. Plasma ADH concentration was less at T3 in dogs that received fluids, compared with those that did not. Blood pressure did not differ between groups, and osmolality did not increase > 1% from T0 value at any time. At T4, rate of urine production was less in dogs that did not receive fluids, compared with those that did. Conclusions and Clinical Relevance—Plasma ADH concentration increased and PCV and TS concentration decreased in response to anesthesia and surgery. Intravenous administration of fluids resulted in increased urine output but had no effect on ADH concentration or arterial BP. The causes and effects of increased plasma ADH concentrations may affect efficacious administration of fluids during the perioperative period in dogs. (Am J Vet Res 2000;61: 1273–1276) |
| Databáze: | OpenAIRE |
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