Amino acid metabolism in euryhaline bivalves: regulation of glycine accumulation in ribbed mussel gills
| Autor: | Stephen H. Bishop, Lehman L. Ellis, James M. Burcham, Kennedy T. Paynter |
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| Rok vydání: | 1985 |
| Předmět: |
Gill
chemistry.chemical_classification Alanine Gills animal structures Catabolism Glyoxylate cycle Glycine General Medicine Metabolism Biology Chemical Fractionation Bivalvia Mitochondria Serine chemistry.chemical_compound Enzyme Biosynthesis chemistry Biochemistry Animals Animal Science and Zoology Amino Acids Oxidation-Reduction |
| Zdroj: | The Journal of experimental zoology. 233(3) |
| ISSN: | 0022-104X |
| Popis: | Glycine levels in isolated ribbed mussel (Modiolus demissus) gill tissue increased slightly and decreased markedly when incubated at high and low salinities, respectively. Low levels of the enzymes involved in the biosynthesis of serine from triose phosphate intermediates, the serine hydroxy-methyltransferase, and serine dehydrase were detected in gill tissue homogenates. Experiments using gill tissue incubated with (U-14C)-glycine and (U-14C)-serine indicated interconversion between serine and glycine and transfer of label to alanine, asparate, glutamate, CO2, organic acids, and protein. Glyoxylate was metabolized more slowly than glycine and was probably converted to glycine for catabolism. Studies using (1-14C)-glycine and (2-14C)-glycine with isolated gill tissue and mitochondria indicated that the mitochondrial glycine cleavage enzyme was the major route of glycine catabolism. Metabolic controls activating or inhibiting the glycine cleavage enzyme regulate tissue glycine accumulation and catabolism during hypersalinity or hyposalinity stress. |
| Databáze: | OpenAIRE |
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