Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences
| Autor: | Darren Price, Fiona Roby, John Sargeant, Andrew C. Calder, Andrew Hilton, Kim Norman, Cheryl Dias, Liana Amunts, Stanimira Georgieva, Adarsh Grewal, Jonathan Dowrick, Tim Dalgleish, Ozlem Yazlik, Karen L. Campbell, Beth L. Parkin, Geoff Hale, Diane Rowland, Abdur Mustafa, Melissa Fair, James B. Rowe, Cheryl Stone, David Samu, Gillian Amery, Kamen A. Tsvetanov, Tibor Auer, Claire J. Hanley, Jodie Allen, Lorraine K. Tyler, Anna Goulding, Fiona E. Matthews, Laura Villis, Maggie Squire, John S. Duncan, Carol Brayne, David Troy, Hayley Fisher, Rogier A. Kievit, Sofia Gerbase, Amanda Castle, Jason R. Taylor, Thea Kavanagh-Williamson, Simon W. Davis, Alison McMinn, Anna McCarrey, Frances Johnson, Jaya Hillman, Janna van Belle, Joanne Mitchell, Anne Barcroft, Magdalena Kwasniewska, Sharon Erzinglioglu, Lauren Bates, Emma Green, Teresa Cheung, Beth Stevens, Marie Dixon, R. Neto Henriques, Rhodri Cusack, Nitin Williams, Meredith A. Shafto, Linda Geerligs, Marta Correia, Richard N. Henson, Matthias S. Treder, Andrew Gadie, Dan Barnes, Cam-CAN, Aldabra Stoddart, Jessica Penrose, Tina Emery, William D. Marslen-Wilson, Edward T. Bullmore, Patricia Johnston, Lu Gao, Tracy Thompson |
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| Přispěvatelé: | Neuroscience Center, Price, D [0000-0002-4786-3976], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging MYELIN Time Factors INFORMATION General Physics and Astronomy FACES Electroencephalography Brain mapping GAUSSIAN WATER DIFFUSION Cohort Studies 0302 clinical medicine Hearing Gray Matter 10. No inequality COGNITIVE PROCESSING SPEED Aged 80 and over Brain Mapping Principal Component Analysis Multidisciplinary medicine.diagnostic_test 05 social sciences Brain Magnetoencephalography Middle Aged Magnetic Resonance Imaging White Matter medicine.anatomical_structure Evoked Potentials Auditory FLUID INTELLIGENCE Female Adult CORTEX Adolescent Auditory evoked field Science Models Neurological Evoked field Grey matter Biology Auditory cortex Article 050105 experimental psychology General Biochemistry Genetics and Molecular Biology White matter Young Adult 03 medical and health sciences BRAIN POTENTIALS medicine Humans 0501 psychology and cognitive sciences Vision Ocular Aged Auditory Cortex 3112 Neurosciences General Chemistry PATTERN Atrophy Neuroscience SYSTEM 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Price, D, Tyler, L K, Henriques, R N, Campbell, K, Williams, N, Treder, M, Taylor, J, Cam-CAN & Henson, R N A 2017, ' Age-related delay in visual and auditory evoked responses is mediated by white-and gray-matter differences ', Nature Communications, vol. 8, 15671 . https://doi.org/10.1038/ncomms15671 Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms15671 |
| Popis: | Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy. Neural processing speed slows with age, but the relationship between this slowing and brain atrophy is unknown. Here, authors show that age-related functional brain differences in auditory and visual processing are partly due to structural differences in the distinct brain regions underlying these processes. |
| Databáze: | OpenAIRE |
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