Developmental pattern of NADPH-diaphorase activity and nitric oxide-stimulated cGMP immunoreactivity in the frontal rat cortex and its role in functional recovery from aspiration lesions
| Autor: | C.G. van Eden, Harry W.M. Steinbusch, A. Rinkens, J. de Vente |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Nitroprusside
medicine.medical_specialty N-Methylaspartate Period (gene) Vasodilator Agents Prefrontal Cortex Nitric Oxide Nitric oxide Cellular and Molecular Neuroscience chemistry.chemical_compound Basal (phylogenetics) Cortex (anatomy) Internal medicine medicine Excitatory Amino Acid Agonists Animals Rats Wistar Prefrontal cortex Cyclic GMP biology Age Factors NADPH Dehydrogenase Immunohistochemistry Rats Nitric oxide synthase medicine.anatomical_structure Endocrinology chemistry Animals Newborn biology.protein NMDA receptor Sodium nitroprusside Neuroscience medicine.drug |
| Zdroj: | Journal of chemical neuroanatomy. 10(3-4) |
| ISSN: | 0891-0618 |
| Popis: | The present study was undertaken to (1) explore the cortical nitric oxide (NO)-system during postnatal development and (2) to see whether or not the NO-system reacts differentially after neonatal and adult lesions of the medial prefrontal cortex. Three aspects of the NO-system were studied, i.e., NADPH-diaphorase (NADPH-d) activity, sodium nitroprusside (SNP)- and N -methyl- d -aspartate (NMDA)-stimulated cGMP-immunoreactivity (cGMP-IR). It was shown that: (1) the development of NADPH-d activity containing cells is continued in the period from P6 until P21; (2) during the same period, large developmental changes take place in basal, and SNP- or NMDA-stimulated cGMP-IR in the cortex. These changes are regionally specific and follow the general cortical developmental pattern; and (3) aspiration lesions do not induce major changes in the distribution of NADPH-d activity or cGMP-IR, either basal, SNP- or NMDA-stimulated. |
| Databáze: | OpenAIRE |
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